Rabbit ANGPTL3 Polyclonal Antibody | anti-ANGPTL3 antibody

ANGPTL3 Rabbit Polyclonal

Cat. Num. AAA766630

• Gene Names: ANGPTL3; ANL3; ANG-5; FHBL2; ANGPT5
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ANGPTL3; Polyclonal Antibody; ANGPTL3 Rabbit Polyclonal; anti-ANGPTL3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 460

• Applicable Applications for anti-ANGPTL3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Angiopoietin-like 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse kidney using MBS766630 (ANGPTL3 antibody) at dilution of 1:100)

Western Blot (WB)

(A375 cells were subjected to SDS PAGE followed by western blot with MBS766630 (ANGPTL3 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 7656888
• NCBI GeneID: 27329
• NCBI Accession #: NP_055310.1
• NCBI GenBank Nucleotide #: NM_014495.3
• Molecular Weight: 53,637 Da
• NCBI Official Full Name: angiopoietin-related protein 3 preproprotein
• NCBI Official Synonym Full Names: angiopoietin like 3
• NCBI Official Symbol: ANGPTL3
• NCBI Official Synonym Symbols: ANL3; ANG-5; FHBL2; ANGPT5
• NCBI Protein Information: angiopoietin-related protein 3
• UniProt Protein Name: Angiopoietin-related protein 3
• Protein Family: Angiopoietin-related protein
• UniProt Gene Name: ANGPTL3
• UniProt Synonym Gene Names: ANGPT5; ANG-5
• UniProt Entry Name: ANGL3_HUMAN

NCBI Description

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]

Uniprot Description

ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: cell surface; early endosome; extracellular space; Golgi apparatus; lamellipodium

Molecular Function: enzyme inhibitor activity; growth factor activity; heparin binding; integrin binding; phospholipase inhibitor activity

Biological Process: acylglycerol homeostasis; angiogenesis; artery morphogenesis; cell-matrix adhesion; cholesterol homeostasis; cholesterol metabolic process; fatty acid metabolic process; glycerol metabolic process; integrin-mediated signaling pathway; lipid homeostasis; negative regulation of lipoprotein lipase activity; phospholipid catabolic process; phospholipid homeostasis; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of lipid catabolic process; response to hormone stimulus; sequestering of lipid; signal transduction

Disease: Hypobetalipoproteinemia, Familial, 2