Western Blot (WB)
(Western Blot analysis of Human fetal brain tissue using CARD14 Polyclonal Antibody at dilution of 1:650)
Rabbit anti-Human CARD14 Polyclonal Antibody | anti-CARD14 antibody
CARD14 Polyclonal Antibody
IHC: 1:25-1:100
Western Blot (WB)
(Western Blot analysis of Human fetal brain tissue using CARD14 Polyclonal Antibody at dilution of 1:650)
Western Blot (WB)
(Western Blot analysis of Human fetal brain tissue using CARD14 Polyclonal Antibody at dilution of 1:650)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer using CARD14 Polyclonal Antibody at dilution of 1:30)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer using CARD14 Polyclonal Antibody at dilution of 1:30)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer using CARD14 Polyclonal Antibody at dilution of 1:30)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer using CARD14 Polyclonal Antibody at dilution of 1:30)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Uniprot Description
CARD14: a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: cytoplasm; plasma membrane
Molecular Function: CARD domain binding
Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; activation of NF-kappaB-inducing kinase; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; activation of NF-kappaB transcription factor
Disease: Psoriasis 2; Pityriasis Rubra Pilaris
Research Articles on CARD14
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Product Notes
The CARD14 card14 (Catalog #AAA2517739) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CARD14 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CARD14 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:200-1:1000 IHC: 1:25-1:100. Researchers should empirically determine the suitability of the CARD14 card14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CARD14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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