Western Blot (WB)
(Western Blot analysis of WDR45 expression in transfected 293T cell line by WDR45 polyclonal antibody. Lane 1: WDR45 transfected lysate (39.71kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human WDR45 Polyclonal Antibody | anti-WDR45 antibody
WDR45 (WD Repeat-containing Protein 45, WD Repeat Domain Phosphoinositide-interacting Protein 4, WIPI4, WIPI-4, WDRX1, WDRXI4, JM5, NBIA4, NBIA5)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Storage and Stability:
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Dilution: Immunofluorescence: 10ug/ml
Western Blot (WB)
(Western Blot analysis of WDR45 expression in transfected 293T cell line by WDR45 polyclonal antibody. Lane 1: WDR45 transfected lysate (39.71kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of WDR45 expression in transfected 293T cell line by WDR45 polyclonal antibody. Lane 1: WDR45 transfected lysate (39.71kD). Lane 2: Non-transfected lysate.)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to WDR45 on HeLa cell. [antibody concentration 10ug/ml])
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to WDR45 on HeLa cell. [antibody concentration 10ug/ml])
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
WDR45: a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]
Protein type: Autophagy
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: extrinsic to membrane; pre-autophagosomal structure membrane; cytosol
Molecular Function: phosphatidylinositol 3-phosphate binding
Biological Process: mitochondrion degradation; protein amino acid lipidation; autophagy; autophagic vacuole formation; cellular response to nitrogen starvation
Disease: Neurodegeneration With Brain Iron Accumulation 5
Research Articles on WDR45
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Product Notes
The WDR45 wdr45 (Catalog #AAA6003674) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The WDR45 (WD Repeat-containing Protein 45, WD Repeat Domain Phosphoinositide-interacting Protein 4, WIPI4, WIPI-4, WDRX1, WDRXI4, JM5, NBIA4, NBIA5) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's WDR45 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the WDR45 wdr45 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS MGLVEMLHRS NLLALVGGGS SPKFSEISVL IWDDAREGKD SKEKLVLEFT FTKPVLSVRM RHDKIVIVLK NRIYVYSFPD NPRKLFEFDT RDNPKGLCDL CPSLEKQLLV FPGHKCGSLQ LVDLASTKPG TSSAPFTINA HQSDIACVSL NQPGTVVASA SQKGTLIRLF DTQSKEKLVE LRRGTDPATL YCINFSHDSS FLCASSDKGT VHIFALKDTR LNRRSALARV GKVGPMIGQY VDSQWSLASF TVPAESACIC AFGRNTSKNV NSVIAICVDG TFHKYVFTPD GNCNREAFDV YLDICDDDDF * Stora ge and Stability: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. It is sometimes possible for the material contained within the vial of "WDR45, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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