Rabbit CARD14 Polyclonal Antibody | anti-CARD14 antibody

Anti-CARD14 Antibody (aa291-340)

Cat. Num. AAA2401092

• Gene Names: CARD14; PRP; PSS1; BIMP2; CARMA2; PSORS2
• Reactivity: Human; Predicted: Mouse
• Applications: ELISA, Immunofluorescence, Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CARD14; Polyclonal Antibody; Anti-CARD14 Antibody (aa291-340); Rabbit Polyclonal (IgG) to Human CARD14; BIMP2; Card-maguk protein 2; Carma 2; PrP; PSORS2; PSS1; CARMA2; anti-CARD14 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CAR14 Antibody detects endogenous levels of total CAR14 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Sequence Length: 1004

• Applicable Applications for anti-CARD14 antibody: ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin
• Application Notes: ELISA: 1:40000; IF: 1:100-1:500; IHC-P: 1:50
• Immunogen: Synthetic peptide from human CAR14 (aa291-340).
• Conjugation: Unconjugated
• Epitope: aa291-340
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-CARD14 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.)

Immunofluorescence (IF)

(Immunofluorescence of MCF7 cells, using CAR14 Antibody. The picture on the right is treated with the synthesized peptide.)

Related Product Information for anti-CARD14 antibody

CARD14 is a caspase recruitment domain-containing protein that is amember of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that areinvolved in a diverse array of cellular processes including cellularadhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known tofunction as a positive regulator of cell apoptosis and NF-kappaBactivation.

NCBI and Uniprot Product Information

• NCBI GI #: 332801087
• NCBI GeneID: 79092
• NCBI Accession #: NP_077015.2
• NCBI GenBank Nucleotide #: NM_024110.4
• UniProt Accession #: Q9BXL6; Q9BVB5; B8QQJ3
• Molecular Weight: 48,505 Da
• NCBI Official Full Name: caspase recruitment domain-containing protein 14 isoform 1
• NCBI Official Synonym Full Names: caspase recruitment domain family member 14
• NCBI Official Symbol: CARD14
• NCBI Official Synonym Symbols: PRP; PSS1; BIMP2; CARMA2; PSORS2
• NCBI Protein Information: caspase recruitment domain-containing protein 14
• UniProt Protein Name: Caspase recruitment domain-containing protein 14
• Protein Family: Caspase recruitment domain-containing protein
• UniProt Gene Name: CARD14
• UniProt Synonym Gene Names: CARMA2; Carma 2

NCBI Description

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Uniprot Description

Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.