Immunohistochemistry (IHC)
(Anti-L1CAM antibody IHC staining of human peripheral nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Rabbit anti-Mouse, Human L1CAM Polyclonal Antibody | anti-L1CAM antibody
Anti-L1CAM Antibody (aa1153-1182) IHC-plus
WB (1:1000)
For long term storage store at -20 degree C.
Immunohistochemistry (IHC)
(Anti-L1CAM antibody IHC staining of human peripheral nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Immunohistochemistry (IHC)
(Anti-L1CAM antibody IHC staining of human peripheral nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Western Blot (WB)
(L1CAM Antibody western blot of Jurkat cell line lysates (35 ug/lane). The L1CAM antibody detected the L1CAM protein (arrow).)
Western Blot (WB)
(L1CAM Antibody western blot of Jurkat cell line lysates (35 ug/lane). The L1CAM antibody detected the L1CAM protein (arrow).)
Western Blot (WB)
(L1CAM Antibody western blot of mouse cerebellum tissue lysates (35 ug/lane). The L1CAM antibody detected the L1CAM protein (arrow).)
Western Blot (WB)
(L1CAM Antibody western blot of mouse cerebellum tissue lysates (35 ug/lane). The L1CAM antibody detected the L1CAM protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
Uniprot Description
NCAM-L1: cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. Two splice-variant isoforms have been described.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cell surface; external side of plasma membrane; focal adhesion; integral to membrane; plasma membrane; presynaptic membrane; terminal button
Molecular Function: identical protein binding; integrin binding; protein self-association; sialic acid binding
Biological Process: axon guidance; blood coagulation; cell adhesion; cell surface receptor linked signal transduction; cell-cell adhesion mediated by integrin; chemotaxis; heterophilic cell adhesion; homophilic cell adhesion; homotypic cell-cell adhesion; leukocyte adhesion; leukocyte migration; nervous system development; positive regulation of axon extension; positive regulation of calcium-mediated signaling; positive regulation of cell-cell adhesion
Disease: Corpus Callosum, Partial Agenesis Of, X-linked; Hydrocephalus Due To Congenital Stenosis Of Aqueduct Of Sylvius; Masa Syndrome
Research Articles on L1CAM
Similar Products
Product Notes
The L1CAM l1cam (Catalog #AAA249582) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-L1CAM Antibody (aa1153-1182) IHC-plus reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's L1CAM can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P (1:100) WB (1:1000). Researchers should empirically determine the suitability of the L1CAM l1cam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "L1CAM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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