Rabbit anti-Human ARHU / RHOU Polyclonal Antibody | anti-ARHU antibody

Rabbit Polyclonal (IgG) to Human ARHU / RHOU

Cat. Num. AAA248981

• Gene Names: RHOU; ARHU; G28K; WRCH1; hG28K; CDC42L1
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: ARHU / RHOU; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human ARHU / RHOU; Anti-ARHU / RHOU Antibody IHC-plus; RHOU; ARHU; CDC42-like GTPase 1; CDC42L1; DJ646B12.2; FJ646B12.2; G28K; GTP-binding protein-like 1; GTP-binding protein SB128; HG28K; GTP-binding protein like 1; Ras homolog family member U; Rho GTPase-like protein ARHU; Ryu GTPase; Human ARHU; anti-ARHU antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human RHOU
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7, 10% Glycerol, 0.01% Thimerosal
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 258

• Applicable Applications for anti-ARHU antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA, IHC-P (10 ug/ml); Usage: Antibody reactive against peptide, detects immunogen.
• Target Species: Human
• Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 11 (Q7L0Q8) of WRCH1. Percent identity by BLAST analysis: Human (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: ARHU / RHOU antibody was raised against synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 11 (Q7L0Q8) of WRCH1. Percent identity by BLAST analysis: Human (100%).
• Preparation and Storage: Aliquot and freeze at -20 degree C. Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-ARHU / RHOU antibody IHC staining of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Product Categories/Family for anti-ARHU antibody

Family: Ras GTPase superfamily IPR001806

NCBI and Uniprot Product Information

• NCBI GI #: 11034843
• NCBI GeneID: 58480
• NCBI Accession #: NP_067028.1
• NCBI GenBank Nucleotide #: NM_021205.5
• UniProt Accession #: Q7L0Q8; Q59FE9; Q8TDQ2; B1AKN1
• Molecular Weight: 22,164 Da
• NCBI Official Full Name: rho-related GTP-binding protein RhoU
• NCBI Official Synonym Full Names: ras homolog family member U
• NCBI Official Symbol: RHOU
• NCBI Official Synonym Symbols: ARHU; G28K; WRCH1; hG28K; CDC42L1
• NCBI Protein Information: rho-related GTP-binding protein RhoU; RHOU; Ryu GTPase; 2310026M05Rik; CDC42-like GTPase 1; GTP-binding protein SB128; GTP-binding protein like 1; rho GTPase-like protein ARHU; ras-like gene family member U; wnt-1 responsive Cdc42 homolog 1; ras homolog gene family, member U
• UniProt Protein Name: Rho-related GTP-binding protein RhoU
• UniProt Gene Name: RHOU
• UniProt Synonym Gene Names: WRCH-1
• UniProt Entry Name: RHOU_HUMAN

NCBI Description

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]

Uniprot Description

RHOU: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Belongs to the small GTPase superfamily. Rho family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric, Rho; G protein, monomeric; Motility/polarity/chemotaxis; G protein

Chromosomal Location of Human Ortholog: 1q42.11-q42.3

Cellular Component: Golgi membrane; cell projection; focal adhesion; plasma membrane; podosome; cytosol

Molecular Function: GTPase activity; protein binding; GTP binding; metal ion binding

Biological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; metabolic process; small GTPase mediated signal transduction; Rac protein signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; G1/S transition of mitotic cell cycle