Rabbit BRS3 / BRS-3 Polyclonal Antibody | anti-BRS3 antibody

Rabbit Polyclonal to Human BRS3 / BRS-3

Cat. Num. AAA240893

• Gene Names: BRS3; BB3
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: BRS3 / BRS-3; Polyclonal Antibody; Rabbit Polyclonal to Human BRS3 / BRS-3; Anti-BRS3 / BRS-3 Antibody (C-Terminus) IHC-plus; BRS3; BB3 receptor; Bombesin-like receptor 3; Bombesin receptor subtype 3; Bombesin receptor subtype-3; BRS-3; BLP receptor subtype 3; Bombesin receptor 3; Human BRS3; anti-BRS3 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human BRS3. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRPR (45%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 399

• Applicable Applications for anti-BRS3 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human BRS3. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Monkey (90%); Bat, Elephant (85%); Horse, Rabbit, Guinea pig (80%).
• Immunogen Type: Synthetic peptide
• Immunogen: BRS3 / BRS-3 antibody was raised against synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human BRS3. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (95%); Monkey (90%); Bat, Elephant (85%); Horse, Rabbit, Guinea pig (80%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-BRS3 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-BRS3 antibody

BRS3 is classified as an Orphan-A Receptor and is highly similar to the bombesin receptors but has a very low affinity for bombesin itself. Mice lacking BRS3 develop metabolic defects and obesity, suggesting that BRS3 may be an important target for obesity research. In addition, BRS3 may be involved in diabetes and hypertension.

Product Categories/Family for anti-BRS3 antibody

Family: GPCR; Subfamily: Orphan-A

NCBI and Uniprot Product Information

• NCBI GI #: 4502455
• NCBI GeneID: 680
• NCBI Accession #: NP_001718.1
• NCBI GenBank Nucleotide #: NM_001727.1
• UniProt Accession #: P32247
• Molecular Weight: 44,411 Da
• NCBI Official Full Name: bombesin receptor subtype-3
• NCBI Official Synonym Full Names: bombesin-like receptor 3
• NCBI Official Symbol: BRS3
• NCBI Official Synonym Symbols: BB3
• NCBI Protein Information: bombesin receptor subtype-3; BRS-3; G-protein coupled receptor; bombesin receptor subtype 3
• UniProt Protein Name: Bombesin receptor subtype-3
• Protein Family: Bombesin receptor
• UniProt Gene Name: BRS3
• UniProt Synonym Gene Names: BRS-3
• UniProt Entry Name: BRS3_HUMAN

NCBI Description

The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

Uniprot Description

BRS3: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: neuron projection; cell soma; plasma membrane; integral to membrane

Molecular Function: bombesin receptor activity

Biological Process: regulation of blood pressure; bombesin receptor signaling pathway; glucose metabolic process; adult feeding behavior