Rabbit GPR98 / VLGR1 Polyclonal Antibody | anti-GPR98 antibody

Rabbit Polyclonal to Human GPR98 / VLGR1

Cat. Num. AAA242615

• Gene Names: GPR98; FEB4; MASS1; USH2B; USH2C; VLGR1; VLGR1b
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey, Dog (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPR98 / VLGR1; Polyclonal Antibody; Rabbit Polyclonal to Human GPR98 / VLGR1; Anti-GPR98 / VLGR1 Antibody (Internal) IHC-plus; GPR98; FEB4; KIAA0686; G-protein coupled receptor 98; MASS1; VLGR1b; Usher syndrome type-2C protein; USH2B; USH2C; G protein-coupled receptor 98; KIAA1943; VLGR1; Human GPR98; anti-GPR98 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Monkey, Dog (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPR98. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 6306

• Applicable Applications for anti-GPR98 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 - 10 ug/ml); Usage: Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from internal region of human GPR98. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (95%); Marmoset, Dog (90%); Mouse, Elephant (85%); Bat, Panda (80%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPR98 / VLGR1 antibody was raised against synthetic 20 amino acid peptide from internal region of human GPR98. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (95%); Marmoset, Dog (90%); Mouse, Elephant (85%); Bat, Panda (80%).
• Antigen Modification: Internal
• Preparation and Storage: Short term: +4 degree C. Long term: aliquot and store at -70 degree C.

Immunohistochemistry (IHC)

(Anti-GPR98 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR98 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPR98 antibody

Very Large G Protein-Coupled Receptor-1 (VLGR1) is an Orphan-A GPCR with an unknown ligand. VLGR1 consists of three expressed isoforms. VLGR1 has a large ectodomain containing multiple CALX-beta repeats that resemble regulatory domains of sodium-calcium exchanger proteins. VLGR1b, which is the only form expressed in mouse, is apparently the largest known cell-surface protein with an ectodomain containing 35 CALX- repeats and a pentraxin homology domain.

Product Categories/Family for anti-GPR98 antibody

Family: GPCR; Subfamily: Orphan-A

NCBI and Uniprot Product Information

• NCBI GI #: 113722120
• NCBI GeneID: 84059
• NCBI Accession #: NP_115495.3
• NCBI GenBank Nucleotide #: NM_032119.3
• UniProt Accession #: Q8WXG9; O75171; Q8TF58; Q9H0X5; Q9UL61
• Molecular Weight: 162,038 Da
• NCBI Official Full Name: G-protein coupled receptor 98
• NCBI Official Synonym Full Names: G protein-coupled receptor 98
• NCBI Official Symbol: GPR98
• NCBI Official Synonym Symbols: FEB4; MASS1; USH2B; USH2C; VLGR1; VLGR1b
• NCBI Protein Information: G-protein coupled receptor 98; usher syndrome type-2C protein; very large G protein-coupled receptor 1; very large G-protein coupled receptor 1; monogenic, audiogenic seizure susceptibility 1 homolog; monogenic audiogenic seizure susceptibility protein 1 homolog
• UniProt Protein Name: G-protein coupled receptor 98
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR98
• UniProt Synonym Gene Names: KIAA0686; KIAA1943; MASS1; VLGR1
• UniProt Entry Name: GPR98_HUMAN

NCBI Description

This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

GPR98: Receptor that may have an important role in the development of the central nervous system. Defects in GPR98 are the cause of Usher syndrome type 2C (USH2C). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4); also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: cell surface; membrane; perinuclear region of cytoplasm; cytoplasm; integral to membrane; receptor complex

Molecular Function: G-protein coupled receptor activity; protein binding; myosin binding; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; nervous system development; inner ear receptor stereocilium organization and biogenesis; cell-cell adhesion; sensory perception of sound; visual perception; sensory perception of light stimulus; photoreceptor cell maintenance; detection of mechanical stimulus involved in sensory perception of sound; maintenance of organ identity; neurological system process

Disease: Febrile Seizures, Familial, 4; Usher Syndrome, Type Iic