Rabbit GPR1 Polyclonal Antibody | anti-GPR1 antibody

Rabbit Polyclonal to Human GPR1

Cat. Num. AAA244037

• Reactivity: Gibbon, Gorilla, Human, Monkey; Predicted Reactivity: Dog, Hamster, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPR1; Polyclonal Antibody; Rabbit Polyclonal to Human GPR1; Anti-GPR1 Antibody (Cytoplasmic Domain) IHC-plus; G-protein coupled receptor 1; G protein-coupled receptor 1; Gpr-1; Human GPR1; anti-GPR1 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Monkey; Predicted Reactivity: Dog, Hamster, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except LONRF2 (47%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 355

• Applicable Applications for anti-GPR1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (15 - 20 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 15 amino acid peptide from 2nd cytoplasmic domain of human GPR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Hamster, Dog, Rabbit (93%); Marmoset, Mouse, Rat, Elephant, Panda (87%); Bovine.
• Immunogen Type: Synthetic peptide
• Immunogen: GPR1 antibody was raised against synthetic 15 amino acid peptide from 2nd cytoplasmic domain of human GPR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Hamster, Dog, Rabbit (93%); Marmoset, Mouse, Rat, Elephant, Panda (87%); Bovine, Horse, Pig, Opossum (80%).
• Antigen Modification: Cytoplasmic Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPR1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPR1 antibody

GPR1 is an Orphan-A GPCR with an unknown ligand. GPR1 was identified in a search for genes responsible for mediating brain reward and may have a role in drug addiction. It has also been shown to act as an HIV coreceptor in kidney mesangial cells (Tokizawa et al., 2000).

Product Categories/Family for anti-GPR1 antibody

Family: GPCR; Subfamily: Orphan-A

NCBI and Uniprot Product Information

• NCBI GI #: 36951012
• NCBI GeneID: 2825
• NCBI Accession #: NP_005270.2
• NCBI GenBank Nucleotide #: NM_005279.3
• UniProt Accession #: P46091; Q53TR9; Q6NVX4; A5JUU6; A8K4L1
• Molecular Weight: 41,431 Da
• NCBI Official Full Name: G-protein coupled receptor 1
• NCBI Official Synonym Full Names: G protein-coupled receptor 1
• NCBI Official Symbol: GPR1
• NCBI Protein Information: G-protein coupled receptor 1; probable G-protein coupled receptor 1
• UniProt Protein Name: G-protein coupled receptor 1
• Protein Family: G protein-coupled receptor
• UniProt Gene Name: GPR1
• UniProt Entry Name: GPR1_HUMAN

Uniprot Description

GPR1: Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: neuron projection; integral to plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding

Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway