Rabbit KANK2 Polyclonal Antibody | anti-KANK2 antibody

Anti-KANK2 Antibody (C-Terminus) IHC-plus

Cat. Num. AAA2400274

• Gene Names: KANK2; SIP; MXRA3; PPKWH; ANKRD25
• Reactivity: Mouse, Rat, Human
• Applications: Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
• Purity: Immunoaffinity purified
• Synonyms: KANK2; Polyclonal Antibody; Anti-KANK2 Antibody (C-Terminus) IHC-plus; Rabbit Polyclonal (IgG) to Human KANK2; Human KANK2; Ankyrin repeat domain 25; KIAA1518; ANKRD25; SIP; SRC-1-interacting protein; SRC1-interacting protein; MXRA3; SRC-1 interacting protein; anti-KANK2 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat, Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Two alternatively spliced transcript variants encoding different isoforms have been identified.
• Purity/Purification: Immunoaffinity purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 851

• Applicable Applications for anti-KANK2 antibody: Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
• Application Notes: IF (20 ug/ml); IHC-P (10 ug/ml); WB (1 ug/ml)
• Immunogen: KANK2 antibody was raised against 16 amino acid peptide near the carboxy terminus of human KANK2.
• Immunogen Description: 16 amino acid peptide near the carboxy terminus of human KANK2.
• Antigen Modification: C-Terminus
• Target Species: Human
• Preparation and Storage: Long term: -20 degree C; Short term: 4 degree C; Avoid repeat freeze-thaw cycles

Immunohistochemistry (IHC)

(Anti-KANK2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC)

(Anti-KANK2 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunofluorescence (IF)

(Immunofluorescence of KANK2 in human kidney tissue with KANK2 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot analysis of KANK2 in mouse brain tissue lysate with KANK2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-KANK2 antibody

KANK2 Antibody, Ankyrin repeat domain 25 Antibody, KIAA1518 Antibody, ANKRD25 Antibody, SIP Antibody, SRC-1-interacting protein Antibody, SRC1-interacting protein Antibody, MXRA3 Antibody, SRC-1 interacting protein Antibody Description: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus.

NCBI and Uniprot Product Information

• NCBI GI #: 74757262
• NCBI GeneID: 25959
• UniProt Accession #: Q63ZY3; Q3KQZ3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210; B0I1P4
• Molecular Weight: 90,044 Da
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 2
• NCBI Official Synonym Full Names: KN motif and ankyrin repeat domains 2
• NCBI Official Symbol: KANK2
• NCBI Official Synonym Symbols: SIP; MXRA3; PPKWH; ANKRD25
• NCBI Protein Information: KN motif and ankyrin repeat domain-containing protein 2
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK2
• UniProt Synonym Gene Names: ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein
• UniProt Entry Name: KANK2_HUMAN

Uniprot Description

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation ().