Rabbit anti-Human KANK2 Polyclonal Antibody | anti-KANK2 antibody

KANK2 Antibody (Center)

Cat. Num. AAA9215779

• Gene Names: KANK2; SIP; MXRA3; PPKWH; ANKRD25
• Reactivity: Human
• Applications: Western Blot
• Synonyms: KANK2; Polyclonal Antibody; KANK2 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein; ANKRD25; KIAA1518; MXRA3; anti-KANK2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This KANK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 343-376 amino acids from the Central region of human KANK2.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 851

• Applicable Applications for anti-KANK2 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-KANK2 Antibody (Center) at 1:2000 dilution + human uterus lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 91 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-KANK2 antibody

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).

References

Zhang Y.,et al.EMBO J. 26:2645-2657(2007). Zhu Y.,et al.Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. Nagase T.,et al.DNA Res. 7:143-150(2000). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 209969812
• NCBI GeneID: 25959
• NCBI Accession #: NP_001129663.1
• NCBI GenBank Nucleotide #: NM_001136191.2
• UniProt Accession #: Q63ZY3; Q3KQZ3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210; B0I1P4
• Molecular Weight: 91174
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 2 isoform 2
• NCBI Official Synonym Full Names: KN motif and ankyrin repeat domains 2
• NCBI Official Symbol: KANK2
• NCBI Official Synonym Symbols: SIP; MXRA3; PPKWH; ANKRD25
• NCBI Protein Information: KN motif and ankyrin repeat domain-containing protein 2
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK2
• UniProt Synonym Gene Names: ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein
• UniProt Entry Name: KANK2_HUMAN

Uniprot Description

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation ().