Western Blot (WB)
(Western blot analysis of KANK2 in mouse brain tissue lysate with KANK2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Rabbit KANK2 Polyclonal Antibody | anti-KANK2 antibody
KANK2 Antibody
Gene Names
KANK2; SIP; MXRA3; PPKWH; ANKRD25
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
KANK2 Antibody is affinity chromatography purified via peptide column.
Synonyms
KANK2; Polyclonal Antibody; KANK2 Antibody; SIP; MXRA3; ANKRD25; KIAA1518; KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; KN motif and ankyrin repeat domains 2; anti-KANK2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Two alternatively spliced transcript variants encoding different isoforms have been identified.
Purity/Purification
KANK2 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
859
Applicable Applications for anti-KANK2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
KANK2 Antibody can be used for detection of KANK2 by Western blot at 1 mug/mL.
Conjugate
Unconjugated
Immunogen
KANK2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human KANK2.
Buffer
KANK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
KANK2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Western Blot (WB)
(Western blot analysis of KANK2 in mouse brain tissue lysate with KANK2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of KANK2 in mouse brain tissue lysate with KANK2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Immunohistochemistry (IHC)
(Immunohistochemistry of KANK2 in human kidney tissue with KANK2 antibody at 2.5 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of KANK2 in human kidney tissue with KANK2 antibody at 2.5 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of KANK2 in human kidney tissue with KANK2 antibody at 20 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of KANK2 in human kidney tissue with KANK2 antibody at 20 μg/ml.)
Related Product Information for anti-KANK2 antibody
KANK2 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK2 (KN motif and ankyrin repeat domain-containing protein 2), was initially identified as a steroid receptor coactivator (SRC) interacting protein (SIP) that could sequester steroid receptor coactivators in the cytoplasm. More recent experiments have shown that while KANK2 is widely expressed, in kidney podocytes, KANK2 localizes to foot processes, suggesting that KANK2 may contribute to controlling actin dynamics in podocyte foot processes.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 95 kDa
Observed: 102 kDa
Observed: 102 kDa
NCBI Official Full Name
KN motif and ankyrin repeat domain-containing protein 2 isoform 1
NCBI Official Synonym Full Names
KN motif and ankyrin repeat domains 2
NCBI Official Symbol
KANK2
NCBI Official Synonym Symbols
SIP; MXRA3; PPKWH; ANKRD25
NCBI Protein Information
KN motif and ankyrin repeat domain-containing protein 2; SRC-interacting protein; SRC1-interacting protein; ankyrin repeat domain 25; SRC-1 interacting protein; SRC-1-interacting protein; matrix-remodelling associated 3; matrix-remodeling-associated protein 3; kidney ankyrin repeat-containing protein 2; ankyrin repeat domain-containing protein 25
UniProt Protein Name
KN motif and ankyrin repeat domain-containing protein 2
Protein Family
UniProt Gene Name
KANK2
UniProt Synonym Gene Names
ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein
UniProt Entry Name
KANK2_HUMAN
Uniprot Description
ANKRD25: a mammalian growth regulatory protein containing five Ankyrin repeats, common protein-protein interaction motifs. Ankyrin repeats are found in proteins with diverse functions including transcriptional initiators, cell-cycle regulators, cytoskeletal, and ion transporters. Three alternatively spliced isoforms have been described.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: mitochondrion; cytoplasm
Molecular Function: protein binding
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; apoptosis; negative regulation of programmed cell death; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway
Disease: Palmoplantar Keratoderma And Woolly Hair
Research Articles on KANK2
1. Using whole-exome sequencing, authors identified a homozygous missense c.2009C>T mutation in KANK2
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Product Notes
The KANK2 kank2 (Catalog #AAA153458) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KANK2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KANK2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). KANK2 Antibody can be used for detection of KANK2 by Western blot at 1 mug/mL. Researchers should empirically determine the suitability of the KANK2 kank2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KANK2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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