Rabbit anti-Human KANK2 Polyclonal Antibody | anti-KANK2 antibody

KANK2 Antibody

Cat. Num. AAA9414209

• Gene Names: KANK2; SIP; MXRA3; PPKWH; ANKRD25
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: KANK2; Polyclonal Antibody; KANK2 Antibody; Ankyrin repeat domain-containing protein 25; SRC-1-interacting protein; SRC1-interacting protein; Matrix-remodeling-associated protein 3; anti-KANK2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total KANK2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 851

• Applicable Applications for anti-KANK2 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Immunohistochemistry: 1:50~1:100; Immunofluorescence: 1:100~1:500
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human KANK2.
• Target Name: KANK2
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human heart tissue using KANK2 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of A549 cells, using KANK2 antibody.)

Related Product Information for anti-KANK2 antibody

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.Nagase T., DNA Res. 7:143-150(2000).Ota T., Nat. Genet. 36:40-45(2004).Olsen J.V., Cell 127:635-648(2006).

Product Categories/Family for anti-KANK2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 209969812
• NCBI GeneID: 25959
• NCBI Accession #: NP_001129663.1
• NCBI GenBank Nucleotide #: NM_001136191.2
• UniProt Accession #: Q63ZY3; Q3KQZ3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210; B0I1P4
• Molecular Weight: 90,044 Da
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 2 isoform 2
• NCBI Official Synonym Full Names: KN motif and ankyrin repeat domains 2
• NCBI Official Symbol: KANK2
• NCBI Official Synonym Symbols: SIP; MXRA3; PPKWH; ANKRD25
• NCBI Protein Information: KN motif and ankyrin repeat domain-containing protein 2
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK2
• UniProt Synonym Gene Names: ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein
• UniProt Entry Name: KANK2_HUMAN

Uniprot Description

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation ().