Goat ADIPOR2 Polyclonal Antibody | anti-ADIPOR2 antibody

GOAT ANTI HUMAN ADIPOR2 (N-TERMINAL)

Cat. Num. AAA224022

• Gene Names: ADIPOR2; PAQR2; ACDCR2
• Reactivity: Mouse (Expected from Sequence), Rat (Expected from Sequence)
• Applications: Immunohistochemistry, Western Blot
• Synonyms: ADIPOR2; Polyclonal Antibody; GOAT ANTI HUMAN ADIPOR2 (N-TERMINAL); anti-ADIPOR2 antibody

• Host: Goat
• Reactivity: Mouse (Expected from Sequence), Rat (Expected from Sequence)
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 386

• Applicable Applications for anti-ADIPOR2 antibody: Immunohistology Paraffin, Western Blot (WB)
• Application Notes: Immunohistology - Paraffin: Minimum Dilution: 1/250;; Western Blotting: Minimum Dilution: 1/1000
• Perservative Stabilisers: 0.1% Sodium Azide (NaN3); 0.1% Bovine Serum Albumin
• Histology Positive Control Tissue: Liver and muscle; Buffer Solution
• Antiserum Preparation: Antiserum to human AdipoR2 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data #1

(Paraffin embedded human liver stained with Goat anti human AdipoR2 (MBS224022))

Testing Data #2

(Paraffin embedded human muscle stained with Goat anti human AdipoR2 (MBS224022))

Related Product Information for anti-ADIPOR2 antibody

Goat anti Human AdipoR2 antibody recognizes an epitope within the N-terminal (NT) region of Adiponectin Receptor protein 2 (AdipoR2), a transmembrane protein and member of the ADIPOR family, expressed mainly in the liver and skeletal muscle, which acts a receptor for both globular and full-length adiponectin. AdipoR2 acts as a mediator of fatty acid oxidation, glucose uptake by adiponectin and increased AMPK, PPARalpha ligand activity, thereby playing an important role in the regulation of glucose and lipid metabolism, and in oxidative stress. Goat anti Human AdipoR2 is reported as suitable for use in immunocytochemistry on acetone fixed cells.

NCBI and Uniprot Product Information

• NCBI GI #: 38261973
• NCBI GeneID: 79602
• NCBI Accession #: NP_078827.2
• NCBI GenBank Nucleotide #: NM_024551.2
• UniProt Accession #: Q86V24; Q53YY5; Q9H737
• Molecular Weight: 43,884 Da
• NCBI Official Full Name: adiponectin receptor protein 2
• NCBI Official Synonym Full Names: adiponectin receptor 2
• NCBI Official Symbol: ADIPOR2
• NCBI Official Synonym Symbols: PAQR2; ACDCR2
• NCBI Protein Information: adiponectin receptor protein 2; progestin and adipoQ receptor family member II
• UniProt Protein Name: Adiponectin receptor protein 2
• Protein Family: Adiponectin receptor protein
• UniProt Gene Name: ADIPOR2
• UniProt Synonym Gene Names: PAQR2
• UniProt Entry Name: ADR2_HUMAN

NCBI Description

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

Uniprot Description

ADIPOR2: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Belongs to the ADIPOR family.

Protein type: Membrane protein, multi-pass; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity

Biological Process: positive regulation of glucose import; hormone-mediated signaling; heart development; adiponectin-mediated signaling pathway; fatty acid oxidation; female pregnancy; negative regulation of cell growth; response to nutrient