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Testing Data (Human testis stained with Mouse anti Human Inhibin alpha, showing Sertoli cells, Leydig cells and spermatogonia. Formalin fixed paraffin processed tissue)

Mouse INHIBIN ALPHA Monoclonal Antibody | anti-INHA antibody

MOUSE ANTI HUMAN INHIBIN ALPHA

Applications
Immunohistochemistry, Immunohistochemistry
Synonyms
INHIBIN ALPHA; Monoclonal Antibody; MOUSE ANTI HUMAN INHIBIN ALPHA; anti-INHA antibody
Ordering
For Research Use Only!
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
R1
Form/Format
Tissue Culture Supernatant - liquid
Sequence Length
366
Applicable Applications for anti-INHA antibody
Immunohistology Frozen, Immunohistology Paraffin*
Application Notes
Immunohistology - Frozen: Minimum Dilution: 1/50; Maximum Dilution: 1/100;
Immunohistology - Paraffin: Minimum Dilution: 1/50; Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Histology Positive Control Tissue
Normal human ovary/testis
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Testing Data

(Human testis stained with Mouse anti Human Inhibin alpha, showing Sertoli cells, Leydig cells and spermatogonia. Formalin fixed paraffin processed tissue)

Testing Data (Human testis stained with Mouse anti Human Inhibin alpha, showing Sertoli cells, Leydig cells and spermatogonia. Formalin fixed paraffin processed tissue)
Related Product Information for anti-INHA antibody
Mouse anti human inhibin alpha antibody, clone R1 recognizes the alpha subunit of the 32 kDa human inhibin. A glycoprotein which acts to suppress follicle-stimulating hormone (FSH) secretion (Groome et al, 1990).Inhibin alpha is expressed in a range of tissues including the endometrium (Mylonas et al, 2004), brain (Uccella et al, 2000), adrenal gland (McCluggage et al, 1998), testis (Bergh and Cajander, 1990) and ovary (Cuevas et al, 1987, Yamoto et al, 1992). The antibody may be of value in the differentiation of adrenocortical tumours, placental and gestational trophoblastic lesions, and sex cord stromal tumours (McCluggage, 2001). In western blotting of bovine follicular fluid, bands at 20, 44 and 57 kDa were reported under reducing conditions using clone R1 (Groome et al, 1991).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39,670 Da
NCBI Official Full Name
inhibin alpha chain preproprotein
NCBI Official Synonym Full Names
inhibin, alpha
NCBI Official Symbol
INHA
NCBI Protein Information
inhibin alpha chain; A-inhibin subunit
UniProt Protein Name
Inhibin alpha chain
Protein Family
UniProt Gene Name
INHA
UniProt Entry Name
INHA_HUMAN

NCBI Description

This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.[provided by RefSeq, Dec 2010]

Uniprot Description

INHA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cell soma; extracellular region

Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: hemoglobin biosynthetic process; negative regulation of B cell differentiation; nervous system development; regulation of cell cycle; male gonad development; signal transduction; negative regulation of follicle-stimulating hormone secretion; negative regulation of cell cycle; regulation of cell proliferation; negative regulation of interferon-gamma biosynthetic process; regulation of apoptosis; response to external stimulus; cell surface receptor linked signal transduction; negative regulation of macrophage differentiation; ovarian follicle development; cell-cell signaling; regulation of MAPKKK cascade; erythrocyte differentiation; negative regulation of phosphorylation; positive regulation of follicle-stimulating hormone secretion; cell cycle arrest; cell differentiation; skeletal development; cell development

Research Articles on INHA

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Product Notes

The INHA inha (Catalog #AAA216700) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's INHIBIN ALPHA can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen, Immunohistology Paraffin*. Immunohistology - Frozen: Minimum Dilution: 1/50; Maximum Dilution: 1/100; Immunohistology - Paraffin: Minimum Dilution: 1/50; Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. Researchers should empirically determine the suitability of the INHA inha for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INHIBIN ALPHA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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