Mouse PI-3 KINASE p85 SUBUNIT ALPHA Monoclonal Antibody | anti-PIK3R1 antibody

MOUSE ANTI PI-3 KINASE p85 SUBUNIT ALPHA

Cat. Num. AAA213983

• Reactivity: Human, Monkey, Mouse, Rat
• Applications: Immunoprecipitation, Western Blot
• Synonyms: PI-3 KINASE p85 SUBUNIT ALPHA; Monoclonal Antibody; MOUSE ANTI PI-3 KINASE p85 SUBUNIT ALPHA; anti-PIK3R1 antibody

• Host: Mouse
• Reactivity: Human, Monkey, Mouse, Rat
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: U13
• Form/Format: Tissue Culture Supernatant - liquid
• Sequence Length: 724

• Applicable Applications for anti-PIK3R1 antibody: Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: Immunoprecipitation: Maximum Dilution: Neat;; Western Blotting: Maximum Dilution: 1/200
• Perservative Stabilisers: 0.09% Sodium Azide; Preparation
• Target Species: Bovine
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-PIK3R1 antibody

Mouse anti PI-3 Kinase p85 Subunit alpha antibody, clone U13 recognizes the SH3 domain of the p85 alpha subunit of bovine PI3 kinase, also known as Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha or PtdIns-3-kinase regulatory subunit p85-alpha. p85 alpha PI3 kinase is a 724 amino acid ~85kDa protein bearing a single Rho-GAP domain, two SH2 domains and a single N-terminal SH3 domain. Multiple isoforms of the protein can be generated by alternative splicing, mouse anti PI-3 Kinase p85 subunit alpha antibody, clone U13 recognizes only those isoforms containing the SH3 domain (isoforms 1 and 4) but not those lacking the domain (isoforms 2,3 and 5). Deficiencies in the expression of the PIK3R1 gene can lead to immunodeficiency Agammaglobulinemia 7, autosomal recessive, diue to the inhibition of B cell development (Conley et al. 2012) and the develpmental condition SHORT syndrome (Chudasama et al. 2013).

NCBI and Uniprot Product Information

• NCBI GI #: 27807039
• NCBI GeneID: 282307
• NCBI Accession #: NP_777000.1
• NCBI GenBank Nucleotide #: NM_174575.1
• Molecular Weight: 83,497 Da
• NCBI Official Full Name: phosphatidylinositol 3-kinase regulatory subunit alpha
• NCBI Official Symbol: PIK3R1
• NCBI Protein Information: phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha
• UniProt Protein Name: Phosphatidylinositol 3-kinase regulatory subunit alpha
• Protein Family: Phosphatidylinositol 3-kinase regulatory
• UniProt Gene Name: PIK3R1
• UniProt Synonym Gene Names: PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha
• UniProt Entry Name: P85A_BOVIN

Uniprot Description

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement ().