Testing Data
(Western Blotting of HEK293 and HepG2 cell lysates with Mouse anti Bovine PI-3 kinase p85 subunit beta (MBS216824), recombinant p85beta is included as a positive control)
Mouse PI-3 KINASE p85 SUBUNIT BETA Monoclonal Antibody | anti-Pik3r2 antibody
MOUSE ANTI PI-3 KINASE p85 SUBUNIT BETA
Purified IgG - liquid
Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000
Preparation
Fusion Partners
Shelf Life: 18 months from date of despatch.
Testing Data
(Western Blotting of HEK293 and HepG2 cell lysates with Mouse anti Bovine PI-3 kinase p85 subunit beta (MBS216824), recombinant p85beta is included as a positive control)
Testing Data
(Western Blotting of HEK293 and HepG2 cell lysates with Mouse anti Bovine PI-3 kinase p85 subunit beta (MBS216824), recombinant p85beta is included as a positive control)
NCBI and Uniprot Product Information
Uniprot Description
PIK3R2: regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Kinase, lipid
Cellular Component: intracellular; phosphoinositide 3-kinase complex; nucleus
Molecular Function: protein binding; protein heterodimerization activity; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity; receptor tyrosine kinase binding; transcription factor binding; protein phosphatase binding
Biological Process: phosphoinositide 3-kinase cascade; protein transport; cellular response to insulin stimulus; regulation of phosphorylation; transport; insulin receptor signaling pathway; positive regulation of transcription factor import into nucleus; cell glucose homeostasis; regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Research Articles on Pik3r2
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Product Notes
The Pik3r2 pik3r2 (Catalog #AAA212045) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PI-3 KINASE p85 SUBUNIT BETA can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen, Immunoprecipitation (IP), Western Blot (WB). Immunoprecipitation: Maximum Dilution: 10 ug/ml; Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/1000. Researchers should empirically determine the suitability of the Pik3r2 pik3r2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PI-3 KINASE p85 SUBUNIT BETA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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