Piccolo Recombinant Protein | PCLO recombinant protein

Recombinant Piccolo (PCLO)

Cat. Num. AAA2123513

• Gene Names: PCLO; ACZ; PCH3
• Applications: SDS-Page, Western Blot
• Purity: >80%
• Synonyms: Piccolo; Recombinant Piccolo (PCLO); ACZ; Aczonin; Presynaptic Cytomatrix Protein; PCLO recombinant protein

• Host: E Coli
• Purity/Purification: >80%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Ala4610~Lys4935
• Sequence Length: 5142

• Applicable Applications for PCLO recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His and GST Tag
• Subcellular Location: Extracellular matrix
• Isoelectric Point: 9.7
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for PCLO recombinant protein

Neuro science

NCBI and Uniprot Product Information

• NCBI GI #: 150378539
• NCBI GeneID: 27445
• NCBI Accession #: NP_149015.2
• NCBI GenBank Nucleotide #: NP_149015.2
• UniProt Accession #: Q9Y6V0
• Molecular Weight: Predicted Molecular Mass: 65.5kDa; Accurate Molecular Mass: 68kDa
• NCBI Official Full Name: protein piccolo isoform 1
• NCBI Official Synonym Full Names: piccolo presynaptic cytomatrix protein
• NCBI Official Symbol: PCLO
• NCBI Official Synonym Symbols: ACZ; PCH3
• NCBI Protein Information: protein piccolo
• UniProt Protein Name: Protein piccolo
• Protein Family: Protein piccolo
• UniProt Gene Name: PCLO
• UniProt Synonym Gene Names: ACZ; KIAA0559
• UniProt Entry Name: PCLO_HUMAN

NCBI Description

The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

piccolo: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 7q21.11

Cellular Component: synaptic vesicle; cytoskeleton; membrane; postsynaptic density; synapse; cell junction

Molecular Function: calcium-dependent phospholipid binding; transporter activity; calcium ion binding; profilin binding

Biological Process: regulation of exocytosis; synaptic vesicle exocytosis; cAMP-mediated signaling; insulin secretion; cytoskeleton organization and biogenesis

Disease: Pontocerebellar Hypoplasia, Type 3