Rat ENDOTHELIN Monoclonal Antibody | anti-EDN2 antibody

RAT ANTI HUMAN ENDOTHELIN

Cat. Num. AAA211599

• Gene Names: EDN2; ET2; ET-2; PPET2
• Applications: Immunohistochemistry
• Synonyms: ENDOTHELIN; Monoclonal Antibody; RAT ANTI HUMAN ENDOTHELIN; anti-EDN2 antibody

• Host: Rat
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 3G10
• Specificity: Reacts with the C terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin. The endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 178

• Applicable Applications for anti-EDN2 antibody: Immunohistology Frozen*, IRMA (IR)
• Application Notes: Immunohistology: Frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.; Immunohistology - Frozen: Application Note: Frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3) ; Preparation
• Immunogen: Synthetic peptide corresponding to the c-terminal region of human endothelin (C,H,L,D,I,I,W), conjugated to BSA.; Buffer Solution
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-EDN2 antibody

Reacts with the C terminal of endothelins 1, 2 and 3. 3G10 does not react with the endothelin precursor molecule, big endothelin. The endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.

NCBI and Uniprot Product Information

• NCBI GI #: 4503463
• NCBI GeneID: 1907
• NCBI Accession #: NP_001947.1
• NCBI GenBank Nucleotide #: NM_001956.4
• Molecular Weight: 19,960 Da
• NCBI Official Full Name: endothelin-2 isoform 1 preproprotein
• NCBI Official Synonym Full Names: endothelin 2
• NCBI Official Symbol: EDN2
• NCBI Official Synonym Symbols: ET2; ET-2; PPET2
• NCBI Protein Information: endothelin-2; preproendothelin 2
• UniProt Protein Name: Endothelin-2
• Protein Family: Endothelin
• UniProt Gene Name: EDN2
• UniProt Synonym Gene Names: ET-2; PPET2
• UniProt Entry Name: EDN2_HUMAN

NCBI Description

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Description

EDN2: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: vasoconstriction; neutrophil chemotaxis; inositol phosphate-mediated signaling; regulation of systemic arterial blood pressure by endothelin; positive regulation of the force of heart contraction by chemical signal; cytokine and chemokine mediated signaling pathway; calcium-mediated signaling; positive regulation of leukocyte chemotaxis; positive regulation of heart rate; thermoregulation; prostaglandin biosynthetic process; vein smooth muscle contraction; hormonal regulation of the force of heart contraction; macrophage chemotaxis; elevation of cytosolic calcium ion concentration; macrophage activation; cell surface receptor linked signal transduction; regulation of vasoconstriction; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; alveolus development; artery smooth muscle contraction