Hyaluronan Synthase 1 (HAS1) Recombinant Protein | HAS1 recombinant protein

Recombinant Hyaluronan Synthase 1 (HAS1)

Cat. Num. AAA2097642

• Gene Names: HAS1; HAS
• Reactivity: Human
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Hyaluronan Synthase 1 (HAS1); Recombinant Hyaluronan Synthase 1 (HAS1); HuHAS1; HA synthase 1; Hyaluronate synthase 1; Hyaluronic acid synthase 1; HAS1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 578

• Applicable Applications for HAS1 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: N-terminal His Tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Fragment: Ser96~Trp394

SDS-Page

Product Categories/Family for HAS1 recombinant protein

Enzyme & Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 167466171
• NCBI GeneID: 3036
• NCBI Accession #: NP_001514.2
• NCBI GenBank Nucleotide #: NM_001523.3
• UniProt Accession #: Q92839; Q14470; Q9NS49
• Molecular Weight: Predicted Molecular Weight: 38.2kDa
• NCBI Official Full Name: hyaluronan synthase 1 isoform 1
• NCBI Official Synonym Full Names: hyaluronan synthase 1
• NCBI Official Symbol: HAS1
• NCBI Official Synonym Symbols: HAS
• NCBI Protein Information: hyaluronan synthase 1
• UniProt Protein Name: Hyaluronan synthase 1
• Protein Family: Hyaluronan synthase
• UniProt Gene Name: HAS1
• UniProt Synonym Gene Names: HAS; HA synthase 1; HuHAS1

NCBI Description

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

HAS1: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate. Belongs to the NodC/HAS family.

Protein type: Cell adhesion; EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: cytoplasm; integral component of plasma membrane; plasma membrane

Molecular Function: hyaluronan synthase activity

Biological Process: cell adhesion; extracellular polysaccharide biosynthetic process; glycosaminoglycan biosynthetic process; hyaluronan biosynthetic process