Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5) Recombinant Protein | LGR5 recombinant protein

Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5)

Cat. Num. AAA2097590

• Gene Names: LGR5; FEX; HG38; GPR49; GPR67; GRP49
• Reactivity: Human
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5); Recombinant Leucine Rich Repeat Containing G Protein Coupled Receptor 5 (LGR5); FEX; GPR49; GPR67; HG38; G Protein-Coupled Receptor 49; LGR5 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 835

• Applicable Applications for LGR5 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: N-terminal His Tag
• Buffer Formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Fragment: Lys107~Val296
• Subcellular Location: Membrane
• Isoelectric Point: 8

Product Categories/Family for LGR5 recombinant protein

CD & Adhesion molecule

NCBI and Uniprot Product Information

• NCBI GI #: 469608416
• NCBI GeneID: 8549
• NCBI Accession #: NP_001264156.1
• NCBI GenBank Nucleotide #: NM_001277227.1
• UniProt Accession #: O75473; Q4VAM0; Q4VAM2; Q9UP75; D8MCT0
• Molecular Weight: Predicted Molecular Weight: 25.2kDa; Accurate Molecular Weight: 25kDa
• NCBI Official Full Name: leucine-rich repeat-containing G-protein coupled receptor 5 isoform 3
• NCBI Official Synonym Full Names: leucine rich repeat containing G protein-coupled receptor 5
• NCBI Official Symbol: LGR5
• NCBI Official Synonym Symbols: FEX; HG38; GPR49; GPR67; GRP49
• NCBI Protein Information: leucine-rich repeat-containing G-protein coupled receptor 5
• UniProt Protein Name: Leucine-rich repeat-containing G-protein coupled receptor 5
• Protein Family: Leucine-rich repeat-containing G-protein coupled receptor
• UniProt Gene Name: LGR5
• UniProt Synonym Gene Names: GPR49; GPR67

NCBI Description

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12q21.1

Cellular Component: integral component of plasma membrane; plasma membrane; trans-Golgi network membrane

Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: G-protein coupled receptor signaling pathway; hair follicle development; inner ear development; oocyte differentiation; regulation of cell proliferation