ODC1 recombinant protein

ODC1, 1-461aa, Human, His tag, E Coli

Cat. Num. AAA204706

• Gene Names: ODC1; ODC
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: ODC1; 1-461aa; Human; His tag; E Coli; Ornithine decarboxylase; ODC; ODC1 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMNNFGNE EFDCHFLDEG FTAKDILDQK INEVSSSDDK DAFYVADLGD ILKKHLRWLK ALPRVTPFYA VKCNDSKAIV KTLAATGTGF DCASKTEIQL VQSLGVPPER IIYANPCKQV SQIKYAANNG VQMMTFDSEV ELMKVARAHP KAKLVLRIAT DDSKAVCRLS VKFGATLRTS RLLLERAKEL NIDVVGVSFH VGSGCTDPET FVQAISDARC VFDMGAEVGF SMYLLDIGGG FPGSEDVKLK FEEITGVINP ALDKYFPSDS GVRIIAEPGR YYVASAFTLA VNIIAKKIVL KEQTGSDDED ESSEQTFMYY VNDGVYGSFN CILYDHAHVK PLLQKRPKPD EKYYSSSIWG PTCDGLDRIV ERCDLPEMHV GDWMLFENMG AYTVAAASTF NGFQRPTIYY VMSGPAWQLM QQFQNPDFPP EVEEQDASTL PVSCAWESGM KRHRAACASA SINV
• Sequence Length: 461

• Applicable Applications for ODC1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for ODC1 recombinant protein

Ornithine decarboxylase, also known as ODC1, is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. ODC1 plays an important role in diverse biological processes, including cell growth, differentiation, transformation and apoptosis. Overexpression of the ODC1 gene plays important roles in cell proliferation and the development of cancer. Recombinant human ODC1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for ODC1 recombinant protein

Metabolism

References

Moshier J A., et al. (1992) Genomics. 1:77-86.; Yang Feng T L., et al. (1996) Genomics. 36:449-458.

NCBI and Uniprot Product Information

• NCBI GI #: 4505489
• NCBI GeneID: 4953
• NCBI Accession #: NP_002530
• NCBI GenBank Nucleotide #: NM_002539.2
• UniProt Accession #: P11926; Q53TU3; Q6LDS9
• Molecular Weight: 53.5 kDa (484aa)
• NCBI Official Full Name: ornithine decarboxylase isoform 1
• NCBI Official Synonym Full Names: ornithine decarboxylase 1
• NCBI Official Symbol: ODC1
• NCBI Official Synonym Symbols: ODC
• NCBI Protein Information: ornithine decarboxylase
• UniProt Protein Name: Ornithine decarboxylase
• Protein Family: Mitochondrial 2-oxodicarboxylate carrier
• UniProt Gene Name: ODC1
• UniProt Synonym Gene Names: ODC

NCBI Description

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Uniprot Description

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.