Bone Morphogenetic Protein 7 (BMP7) Recombinant Protein | BMP7 recombinant protein

Recombinant Bone Morphogenetic Protein 7 (BMP7)

Cat. Num. AAA2012167

• Gene Names: Bmp7; OP1
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Bone Morphogenetic Protein 7 (BMP7); Recombinant Bone Morphogenetic Protein 7 (BMP7); BMP7 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGS-STGGKQRSQ NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR NMVVRACGCH
• Sequence Length: 430

• Applicable Applications for BMP7 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Mus musculus (Mouse)
• Expression System: Prokaryotic expression
• Residues: Ser292~His430 (Accession # P23359) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 31982487
• NCBI GeneID: 12162
• NCBI Accession #: NP_031583.2
• NCBI GenBank Nucleotide #: NM_007557.3
• UniProt Accession #: P23359; Q91XF7
• Molecular Weight: 16.9kDa
• NCBI Official Full Name: bone morphogenetic protein 7 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 7
• NCBI Official Symbol: Bmp7
• NCBI Official Synonym Symbols: OP1
• NCBI Protein Information: bone morphogenetic protein 7; osteogenic protein 1
• UniProt Protein Name: Bone morphogenetic protein 7
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: Bmp7
• UniProt Synonym Gene Names: Bmp-7; Op1; BMP-7; OP-1
• UniProt Entry Name: BMP7_MOUSE

NCBI Description

This gene encodes a member of a family of secreted factors that participate in developmental signal transduction to stimulate SMAD transcriptional activators. Mutation of this gene results in skeletal, kidney, and other developmental defects. The propeptide is further cleaved into an active chain. [provided by RefSeq, Mar 2013]

Uniprot Description

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: negative regulation of MAP kinase activity; axon guidance; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; multicellular organismal development; embryonic pattern specification; negative regulation of cell cycle; negative regulation of neurogenesis; BMP signaling pathway; negative regulation of cell proliferation; epithelial cell differentiation; ureteric bud development; salivary gland morphogenesis; anatomical structure formation; cell differentiation; kidney development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; regulation of phosphorylation; positive regulation of bone mineralization; pattern specification process; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; organ morphogenesis; negative regulation of neuron differentiation; camera-type eye morphogenesis; mesenchymal cell differentiation; branching morphogenesis of a tube; eye development; mesoderm formation; cartilage development; regulation of MAPKKK cascade; negative regulation of mitosis; negative regulation of Notch signaling pathway; negative regulation of phosphorylation; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; tube morphogenesis; positive regulation of cell differentiation; positive regulation of neuron differentiation; cell development; neurite morphogenesis; growth