B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L) Recombinant Protein | Bcl2L recombinant protein
Recombinant B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L)
MGHHHHHHSGSEF-SQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDLYGNNAA AESRKGQERF NR
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
NCBI Description
inhibits neuronal apoptosis; may provide neuroprotection against ischemic brian injury [RGD, Feb 2006]
Uniprot Description
Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.
Protein type: Autophagy; Apoptosis; Mitochondrial; Membrane protein, integral
Cellular Component: mitochondrial envelope; centrosome; nuclear membrane; synaptic vesicle membrane; mitochondrion; integral to membrane; cytosol; mitochondrial outer membrane; mitochondrial matrix; mitochondrial inner membrane; mitochondrial membrane; cytoplasm; nucleolus; intracellular; nucleus; cell junction
Molecular Function: BH domain binding; identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; caspase inhibitor activity; BH3 domain binding; protein kinase binding
Biological Process: response to peptide hormone stimulus; apoptosis; positive regulation of apoptosis; negative regulation of caspase activity; cellular process regulating host cell cycle in response to virus; response to organic cyclic substance; germ cell development; regulation of apoptosis; response to radiation; regulation of mitochondrial membrane potential; ovarian follicle development; positive regulation of cell proliferation; negative regulation of neuron apoptosis; response to electrical stimulus; release of cytochrome c from mitochondria; response to inorganic substance; in utero embryonic development; response to virus; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; endocytosis; response to organic nitrogen; cell proliferation; neuron apoptosis; fertilization; response to hydrogen peroxide; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; response to lead ion; response to hypoxia; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; response to oxidative stress; negative regulation of apoptosis; growth
Research Articles on Bcl2L
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Product Notes
The Bcl2L bcl2l1 (Catalog #AAA2011738) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the Bcl2L bcl2l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-SQSNRE LVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIASWM ATYLNDHLEP WIQENGGWDT FVDLYGNNAA AESRKGQERF NR. It is sometimes possible for the material contained within the vial of "B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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