BAG2 cdna clone

BAG2

Cat. Num. AAA200603

• Gene Names: BAG2; BAG-2; dJ417I1.2
• Synonyms: BAG2; BAG-2; dJ417I1.2; BAG2 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGCTCAGG CGAAGATCAA CGCTAAAGCC AACGAGGGGC GCTTCTGCCG CTCCTCCTCC ATGGCTGACC GCTCCAGCCG CCTGCTGGAG AGCCTGGACC AGCTGGAGCT CAGGGTTGAA GCTTTGAGAG AAGCAGCAAC TGCTGTTGAG CAAGAGAAAG AAATCCTTCT GGAAATGATC CACAGTATCC AAAATAGCCA GGACATGAGG CAGATCAGTG ACGGAGAAAG AGAAGAATTA AATCTGACTG CAAACCGTTT GATGGGAAGA ACTCTCACCG TTGAAGTGTC AGTAGAAACA ATTAGAAACC CCCAGCAGCA AGAATCCCTA AAGCATGCCA CAAGGATTAT TGATGAGGTG GTCAATAAGT TTCTGGATGA TTTGGGAAAT GCCAAGAGTC ATTTAATGTC GCTCTACAGT GCATGTTCAT CTGAGGTGCC ACATGGGCCA GTTGATCAGA AGTTTCAATC CATAGTAATT GGCTGTGCTC TTGAAGATCA GAAGAAAATT AAGAGAAGAT TAGAGACTCT GCTTAGAAAT ATTGAAAACT CTGACAAGGC CATCAAGCTA TTAGAGCATT CTAAAGGAGC TGGTTCCAAA ACTCTGCAAC AAAATGCTGA AAGCAGATTC AATTAG; ; Translation Sequence: MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK TLQQNAESRF N
• Sequence Length: 211

• Species: Human
• Chromosome Location: 6p12.1-p11.2
• OMIM Reference Number: 603882
• cDNA Size: 636bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for BAG2 cdna clone

BCL2-associated athanogene 2, also known as BAG2, is a member of the Bag family of proteins. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain. BAG2 is a major component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to disrupt CHIP-mediated ubiquitylation.

Product Categories/Family for BAG2 cdna clone

Heat Shock Proteins; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4757834
• NCBI GeneID: 9532
• NCBI Accession #: NP_004273.1
• NCBI GenBank Nucleotide #: NM_004282.3
• UniProt Accession #: O95816
• NCBI Official Full Name: BAG family molecular chaperone regulator 2
• NCBI Official Synonym Full Names: BCL2 associated athanogene 2
• NCBI Official Symbol: BAG2
• NCBI Official Synonym Symbols: BAG-2; dJ417I1.2
• NCBI Protein Information: BAG family molecular chaperone regulator 2
• UniProt Protein Name: BAG family molecular chaperone regulator 2
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: BAG2
• UniProt Synonym Gene Names: BAG-2
• UniProt Entry Name: BAG2_HUMAN

NCBI Description

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

Uniprot Description

BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 6p12.1-p11.2

Molecular Function: identical protein binding; protein binding; chaperone binding

Biological Process: protein folding; protein metabolic process