Rabbit Bnip3L (IN) Antibody | anti-BNIP3L antibody

Anti-Bnip3L (IN) Antibody

Cat. Num. AAA194037

• Gene Names: BNIP3L; NIX; BNIP3a
• Applications: Immunoblot, Western Blot
• Synonyms: Bnip3L (IN); Anti-Bnip3L (IN) Antibody; Anti-Bnip3L (IN); anti-BNIP3L antibody

• Host: Rabbit
• Specificity: Anti-Bnip3L (IN) [Rabbit antibody to peptide corresponding to aa 77-92 of human Bnip3L. Recognizes human and mouse Bnip3L.]; This antibody recognizes monomeric human and mouse Bnip3L. A band of 40 kD is detected in immunoblots.
• Form/Format: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

• Applicable Applications for anti-BNIP3L antibody: Immunoblot
• Application Notes: Immunoblotting: use at 0.5-1.0 ug/ml.; Positive control: Whole cell lysate of human K562 cells.
• Antigen: Peptide corresponding to aa 77- 92 of human Bnip3L. This amino acid sequence is identical to that of mouse.
• Stabilizer: None
• Preservatives: 0.02% sodium azide.
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Related Product Information for anti-BNIP3L antibody

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain, and BH3 domain-containing pro-apoptotic proteins (such as Bad, Bax, Bid, Bik, and Hrk) form a growing subclass of the Bcl-2 family. A novel BH3 domain-containing protein was recently identified and designated Bnip3L, Bnip3 alpha , or Nix. Bnip3L is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppression by Bcl-2 and BclxL. Bnip3L is localized in mito-chondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic-mitochondrial proteins.

Product Categories/Family for anti-BNIP3L antibody

Apoptosis Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 4757860
• NCBI GeneID: 665
• NCBI Accession #: NP_004322.1
• NCBI GenBank Nucleotide #: NM_004331.2
• UniProt Accession #: O60238; Q5JW63; Q8NF87; Q6IBV1; Q9H3K3
• Molecular Weight: 23,930 Da
• NCBI Official Full Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
• NCBI Official Synonym Full Names: BCL2/adenovirus E1B 19kDa interacting protein 3-like
• NCBI Official Symbol: BNIP3L
• NCBI Official Synonym Symbols: NIX; BNIP3a
• NCBI Protein Information: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; OTTHUMP00000125280; OTTHUMP00000225446; OTTHUMP00000225447; OTTHUMP00000225448; OTTHUMP00000225568; NIP3-like protein X; adenovirus E1B19k-binding protein B5; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
• UniProt Protein Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
• Protein Family: BCL2/adenovirus E1B 19 kDa protein-interacting protein
• UniProt Gene Name: BNIP3L
• UniProt Synonym Gene Names: BNIP3A; BNIP3H; NIX
• UniProt Entry Name: BNI3L_HUMAN

NCBI Description

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq]

Uniprot Description

BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family.

Protein type: Apoptosis; Membrane protein, integral; Nuclear envelope; Endoplasmic reticulum; Mitochondrial

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; integral to membrane; nuclear envelope; intrinsic to membrane

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; lamin binding

Biological Process: viral reproduction; positive regulation of apoptosis; defense response to virus; negative regulation of apoptosis