Western Blot (WB)
(Anti- Tyrosine Hydroxylase Picoband antibody, MBS178217, Western blottingAll lanes: Anti Tyrosine Hydroxylase (MBS178217) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 59KDObserved bind size: 59KD )
TH Polyclonal Antibody | anti-TH antibody
Anti-TH Antibody
Predicted to work with: Human
Predicted to work with: Human
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- Tyrosine Hydroxylase Picoband antibody, MBS178217, Western blottingAll lanes: Anti Tyrosine Hydroxylase (MBS178217) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 59KDObserved bind size: 59KD )
Western Blot (WB)
(Anti- Tyrosine Hydroxylase Picoband antibody, MBS178217, Western blottingAll lanes: Anti Tyrosine Hydroxylase (MBS178217) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 59KDObserved bind size: 59KD )
Immunohistochemistry (IHC)
(Anti- Tyrosine Hydroxylase Picoband antibody, MBS178217,IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti- Tyrosine Hydroxylase Picoband antibody, MBS178217,IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti- TH Picoband antibody, MBS178217,IHC(P)IHC(P): Rat Brain Tissue )
Immunohistochemistry (IHC)
(Anti- TH Picoband antibody, MBS178217,IHC(P)IHC(P): Rat Brain Tissue )
Background: TH is equal to tyrosine hydroxylase. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TH: an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described.
Protein type: Mitochondrial; Oxidoreductase; Vesicle; Endoplasmic reticulum; EC 1.14.16.2; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; dendrite; internal side of plasma membrane; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal button
Molecular Function: amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; oxygen binding; protein binding; protein domain specific binding; tyrosine 3-monooxygenase activity
Biological Process: anatomical structure morphogenesis; catecholamine biosynthetic process; cerebral cortex development; circadian sleep/wake cycle; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; heart morphogenesis; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organismal aging; neurotransmitter biosynthetic process; norepinephrine biosynthetic process; organ morphogenesis; phthalate metabolic process; phytoalexin metabolic process; pigmentation; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone stimulus; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to light stimulus; response to lipopolysaccharide; response to nutrient levels; response to peptide hormone stimulus; response to pyrethroid; response to salt stress; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; synaptic vesicle amine transport; terpene metabolic process; visual perception
Disease: Segawa Syndrome, Autosomal Recessive
Research Articles on TH
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Product Notes
The TH th (Catalog #AAA178217) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-TH Antibody reacts with Mouse, Rat Predicted to work with: Human and may cross-react with other species as described in the data sheet. AAA Biotech's TH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the TH th for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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