Western Blot (WB)
(Anti-TIMP4 antibody, MBS175349, Western blottingAll lanes: Anti TIMP4 (MBS175349) at 0.5ug/mlLane 1: Rat Kidney Tissue Lysate at 50ugLane 2: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 25KDObserved bind size: 25KD )
Rabbit TIMP4 Polyclonal Antibody | anti-TIMP4 antibody
Anti-TIMP4 antibody
Western Blot (WB)
(Anti-TIMP4 antibody, MBS175349, Western blottingAll lanes: Anti TIMP4 (MBS175349) at 0.5ug/mlLane 1: Rat Kidney Tissue Lysate at 50ugLane 2: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 25KDObserved bind size: 25KD )
Western Blot (WB)
(Anti-TIMP4 antibody, MBS175349, Western blottingAll lanes: Anti TIMP4 (MBS175349) at 0.5ug/mlLane 1: Rat Kidney Tissue Lysate at 50ugLane 2: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 25KDObserved bind size: 25KD )
Immunohistochemistry (IHC)
(Anti-TIMP4 antibody, MBS175349, IHC(P) IHC(P): Rat Kidney Tissue )
Immunohistochemistry (IHC)
(Anti-TIMP4 antibody, MBS175349, IHC(P) IHC(P): Rat Kidney Tissue )
Immunohistochemistry (IHC)
(Anti-TIMP4 antibody, MBS175349, IHC(P) IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-TIMP4 antibody, MBS175349, IHC(P) IHC(P): Human Mammary Cancer Tissue )
Background: The tissue inhibitors of metalloproteinases(TIMPs) inhibit matrix metalloproteinases(MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 gene is mapped to chromosome 3p25. TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]
Uniprot Description
TIMP4: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9. Belongs to the protease inhibitor I35 (TIMP) family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3p25
Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere
Molecular Function: metalloendopeptidase inhibitor activity; protease binding; metal ion binding
Biological Process: response to drug; response to peptide hormone stimulus; negative regulation of metalloenzyme activity; central nervous system development; ovulation cycle; response to cytokine stimulus; response to hormone stimulus; response to lipopolysaccharide; negative regulation of membrane protein ectodomain proteolysis
Research Articles on TIMP4
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Product Notes
The TIMP4 timp4 (Catalog #AAA175349) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TIMP4 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TIMP4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the TIMP4 timp4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIMP4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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