ADRM1 recombinant protein

Recombinant Human ADRM1 protein

Cat. Num. AAA1562197

• Gene Names: ADRM1; ARM1; ARM-1; GP110
• Purity: >90% as determined by SDS-PAGE
• Synonyms: ADRM1; Recombinant Human ADRM1 protein; Proteasomal ubiquitin receptor ADRM1; 110kDa cell membrane glycoprotein; Gp110; Adhesion-regulating molecule 1; ARM-1; Proteasome regulatory particle non-ATPase 13; hRpn13; Rpn13 homolog; ADRM1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human ADRM1 (Thr2-Asp407) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for ADRM1 recombinant protein

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.

Product Categories/Family for ADRM1 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 20141265
• NCBI GeneID: 11047
• UniProt Accession #: Q16186; Q96FJ7; Q9H1P2; A0PKB1
• Molecular Weight: 407
• NCBI Official Full Name: Proteasomal ubiquitin receptor ADRM1
• NCBI Official Synonym Full Names: adhesion regulating molecule 1
• NCBI Official Symbol: ADRM1
• NCBI Official Synonym Symbols: ARM1; ARM-1; GP110
• NCBI Protein Information: proteasomal ubiquitin receptor ADRM1; rpn13 homolog; M(r) 110,000 surface antigen; 110 kDa cell membrane glycoprotein; proteasome regulatory particle non-ATPase 13
• UniProt Protein Name: Proteasomal ubiquitin receptor ADRM1
• UniProt Gene Name: ADRM1
• UniProt Synonym Gene Names: GP110; Gp110; ARM-1; hRpn13
• UniProt Entry Name: ADRM1_HUMAN

NCBI Description

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

ADRM1: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. Interacts with PSMD1, ubiquitin and UCHL5. Belongs to the ADRM1 family.

Protein type: Proteasome complex; Cell development/differentiation

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: proteasome complex; nucleoplasm; membrane; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; protease binding

Biological Process: RNA elongation from RNA polymerase II promoter; proteasome assembly