Western Blot (WB)
(Western blot detection of ADRM1 in K562,Hela cell lysates using ADRM1 Rabbit pAb(1:1000 diluted). Predicted band size:42kDa. Observed band size:42kDa.)
Rabbit anti-Human ADRM1/ARM-1 Polyclonal Antibody | anti-ADRM1 antibody
ADRM1/ARM-1 Rabbit pAb
IHC: 1:20
ICC/IF: 1:20
FC/FACS: 1:20-1:100
IP: 1:20
Western Blot (WB)
(Western blot detection of ADRM1 in K562,Hela cell lysates using ADRM1 Rabbit pAb(1:1000 diluted). Predicted band size:42kDa. Observed band size:42kDa.)
Western Blot (WB)
(Western blot detection of ADRM1 in K562,Hela cell lysates using ADRM1 Rabbit pAb(1:1000 diluted). Predicted band size:42kDa. Observed band size:42kDa.)
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
ADRM1: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. Interacts with PSMD1, ubiquitin and UCHL5. Belongs to the ADRM1 family.
Protein type: Proteasome complex; Cell development/differentiation
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: proteasome complex; nucleoplasm; membrane; integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: protein binding; protease binding
Biological Process: RNA elongation from RNA polymerase II promoter; proteasome assembly
Research Articles on ADRM1
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Product Notes
The ADRM1 adrm1 (Catalog #AAA4751778) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ADRM1/ARM-1 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADRM1/ARM-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), Immunoprecipitation (IP). WB: 1:2000-1:10,000 IHC: 1:20 ICC/IF: 1:20 FC/FACS: 1:20-1:100 IP: 1:20. Researchers should empirically determine the suitability of the ADRM1 adrm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADRM1/ARM-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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