Western Blot (WB)
(Western blot analysis of PRRX1 in HeLa cell lysate with PRRX1 antibody at 1 μg/ml.)
Rabbit PRRX1 Polyclonal Antibody | anti-PRRX1 antibody
PRRX1 Antibody
Western Blot (WB)
(Western blot analysis of PRRX1 in HeLa cell lysate with PRRX1 antibody at 1 μg/ml.)
Western Blot (WB)
(Western blot analysis of PRRX1 in HeLa cell lysate with PRRX1 antibody at 1 μg/ml.)
NCBI and Uniprot Product Information
Observed: 26 kDa
NCBI Description
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]
Uniprot Description
PRRX1: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. Defects in PRRX1 are the cause of agnathia-otocephaly complex (AGOTC). AGOTC is a rare condition characterized by mandibular hypoplasia or agnathia, ventromedial auricular malposition (melotia) and/or auricular fusion (synotia), and microstomia with oroglossal hypoplasia or aglossia. Holoprosencephaly is the most commonly identified association, but skeletal, genitourinary, and cardiovascular anomalies, and situs inversus have been reported. The disorder is almost always lethal. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1q24
Cellular Component: nucleolus; nucleus
Molecular Function: sequence-specific DNA binding; transcription coactivator activity
Biological Process: inner ear morphogenesis; cartilage development; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; artery morphogenesis; embryonic cranial skeleton morphogenesis; negative regulation of transcription from RNA polymerase II promoter; palate development; middle ear morphogenesis; embryonic limb morphogenesis
Disease: Agnathia-otocephaly Complex
Research Articles on PRRX1
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Product Notes
The PRRX1 prrx1 (Catalog #AAA153617) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PRRX1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PRRX1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). PRRX1 antibody can be used for detection of PRRX1 by Western blot at 1 - 2 mug/ml. Researchers should empirically determine the suitability of the PRRX1 prrx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRRX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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