IPR1 Blocking Peptide | SP110 blocking peptide

IPR1 Peptide

Cat. Num. AAA152116

• Gene Names: SP110; IPR1; VODI; IFI41; IFI75
• Applications: Blocking (BL)
• Synonyms: IPR1; IPR1 Peptide; VODI; IFI41; IFI75; Sp110 nuclear body protein; Speckled 110 kDa; SP110 nuclear body protein; SP110 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 549

• Applicable Applications for SP110 blocking peptide: Blocking (BL)
• Application Notes: IPR1 peptide is used for blocking the activity of IPR1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids near the amino terminus of human IPR1.
• Preparation and Storage: Store IPR1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 190343008
• NCBI GeneID: 3431
• NCBI Accession #: NP_004501
• NCBI GenBank Nucleotide #: NM_004510.3
• UniProt Accession #: Q9HB58; Q14976; Q14977; Q53TG2; Q8WUZ6; Q9HCT8; B4DVI4; F5H1M1
• Molecular Weight: 62,603 Da
• NCBI Official Full Name: sp110 nuclear body protein isoform b
• NCBI Official Synonym Full Names: SP110 nuclear body protein
• NCBI Official Symbol: SP110
• NCBI Official Synonym Symbols: IPR1; VODI; IFI41; IFI75
• NCBI Protein Information: sp110 nuclear body protein; speckled 110 kDa; phosphoprotein 41; phosphoprotein 75; interferon-induced protein 41/75; transcriptional coactivator Sp110; interferon-induced protein 41, 30kD; interferon-induced protein 75, 52kD
• UniProt Protein Name: Sp110 nuclear body protein
• Protein Family: Sp110 nuclear body protein
• UniProt Gene Name: SP110
• UniProt Entry Name: SP110_HUMAN

NCBI Description

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

SP110: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI). VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nucleolus; nucleus

Molecular Function: signal transducer activity; DNA binding; zinc ion binding; chromatin binding

Biological Process: chromatin remodeling; viral reproduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; signal transduction

Disease: Mycobacterium Tuberculosis, Susceptibility To; Hepatic Venoocclusive Disease With Immunodeficiency