Rabbit TMEM38B Polyclonal Antibody | anti-TMEM38B antibody

TMEM38B Antibody

Cat. Num. AAA150815

• Gene Names: TMEM38B; OI14; TRICB; TRIC-B; C9orf87; D4Ertd89e; bA219P18.1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: TMEM38B Antibody is affinity chromatography purified via peptide column.
• Synonyms: TMEM38B; Polyclonal Antibody; TMEM38B Antibody; OI14; TRICB; TRIC-B; C9orf87; D4Ertd89e; bA219P18.1; Trimeric intracellular cation channel type B; Transmembrane protein 38B; transmembrane protein 38B; anti-TMEM38B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: TMEM38B Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 291

• Applicable Applications for anti-TMEM38B antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: TMEM38B antibody can be used for detection of TMEM38B by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: TMEM38B antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38B.
• Buffer: TMEM38B Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TMEM38B antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TMEM38B in rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of TMEM38B in mouse thymus tissue with TMEM38B antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of TMEM38B in mouse thymus tissue with TMEM38B antibody at 20 μg/mL.)

Related Product Information for anti-TMEM38B antibody

TMEM38B Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

NCBI and Uniprot Product Information

• NCBI GI #: 8922461
• NCBI GeneID: 55151
• NCBI Accession #: NP_060582
• NCBI GenBank Nucleotide #: NM_018112.2
• UniProt Accession #: Q9NVV0; Q5JR63; Q5SVN5; Q5SVN6; Q5VTE2; Q6IA97
• Molecular Weight: 32,510 Da
• NCBI Official Full Name: trimeric intracellular cation channel type B
• NCBI Official Synonym Full Names: transmembrane protein 38B
• NCBI Official Symbol: TMEM38B
• NCBI Official Synonym Symbols: OI14; TRICB; TRIC-B; C9orf87; D4Ertd89e; bA219P18.1
• NCBI Protein Information: trimeric intracellular cation channel type B
• UniProt Protein Name: Trimeric intracellular cation channel type B
• Protein Family: Trimeric intracellular cation channel
• UniProt Gene Name: TMEM38B
• UniProt Synonym Gene Names: C9orf87; TRIC-B; TRICB
• UniProt Entry Name: TM38B_HUMAN

NCBI Description

This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]

Uniprot Description

TMEM38B: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Belongs to the TMEM38 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q31.2

Cellular Component: nuclear membrane; sarcoplasmic reticulum membrane; integral to membrane; nucleus

Molecular Function: potassium channel activity

Disease: Osteogenesis Imperfecta, Type Xiv