Rabbit anti-Human TMEM38B Polyclonal Antibody | anti-TMEM38B antibody

TMEM38B, CT (Trimeric Intracellular Cation Channel Type B, TRIC-B, TRICB, Transmembrane Protein 38B, C9orf87)

Cat. Num. AAA647161

• Gene Names: TMEM38B; OI14; TRICB; TRIC-B; C9orf87; D4Ertd89e; bA219P18.1; RP11-219P18.1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: TMEM38B; Polyclonal Antibody; CT (Trimeric Intracellular Cation Channel Type B; TRIC-B; TRICB; Transmembrane Protein 38B; C9orf87); Anti -TMEM38B; anti-TMEM38B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human TMEM38B. Species sequence homology: Mouse, rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-TMEM38B antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1-2ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to human TMEM38B at C-terminal conjugated to KLH.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of TMEM38B in rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2ug/ml.)

Related Product Information for anti-TMEM38B antibody

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

Product Categories/Family for anti-TMEM38B antibody

Antibodies; Abs to Membrane Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 8922461
• NCBI GeneID: 55151
• NCBI Accession #: NP_060582.1
• NCBI GenBank Nucleotide #: NM_018112.2
• UniProt Accession #: Q9NVV0; Q5JR63; Q5SVN5; Q5SVN6; Q5VTE2; Q6IA97
• Molecular Weight: 32,510 Da
• NCBI Official Full Name: trimeric intracellular cation channel type B
• NCBI Official Synonym Full Names: transmembrane protein 38B
• NCBI Official Symbol: TMEM38B
• NCBI Official Synonym Symbols: OI14; TRICB; TRIC-B; C9orf87; D4Ertd89e; bA219P18.1; RP11-219P18.1
• NCBI Protein Information: trimeric intracellular cation channel type B
• UniProt Protein Name: Trimeric intracellular cation channel type B
• Protein Family: Trimeric intracellular cation channel
• UniProt Gene Name: TMEM38B
• UniProt Synonym Gene Names: C9orf87; TRIC-B; TRICB
• UniProt Entry Name: TM38B_HUMAN

NCBI Description

This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]

Uniprot Description

Function: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores

By similarity.

Subunit structure: Homotrimer

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

By similarity.

Domain: The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore

By similarity.

Involvement in disease: Osteogenesis imperfecta 14 (OI14) [MIM:615066]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI14 is characterized by variable degrees of severity of multiple fractures and osteopenia, with normal teeth, sclerae, and hearing. Fractures first occur prenatally or by age 6 years.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10

Sequence similarities: Belongs to the TMEM38 family.

Sequence caution: The sequence CAH71458.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12390.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12391.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI12392.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI39690.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI39691.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI39692.1 differs from that shown. Reason: Erroneous gene model prediction.