Western Blot (WB)
(Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Rabbit TMEM38A Polyclonal Antibody | anti-TMEM38A antibody
TMEM38A Antibody
Gene Names
TMEM38A; TRICA; TRIC-A
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunofluorescence
Purity
TMEM38A Antibody is affinity chromatography purified via peptide column.
Synonyms
TMEM38A; Polyclonal Antibody; TMEM38A Antibody; TRICA; TRIC-A; Trimeric intracellular cation channel type A; Transmembrane protein 38A; transmembrane protein 38A; anti-TMEM38A antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
TMEM38A Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
299
Applicable Applications for anti-TMEM38A antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes
TMEM38A antibody can be used for detection of TMEM38A by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
TMEM38A antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38A.
Buffer
TMEM38A Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TMEM38A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of TMEM38A in rat skeletal muscle tissue lysate with TMEM38A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)
Immunofluorescence (IF)
(Immunofluorescence of TMEM38A in mouse skeletal muscle tissue with TMEM38A antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of TMEM38A in mouse skeletal muscle tissue with TMEM38A antibody at 20 μg/mL.)
Related Product Information for anti-TMEM38A antibody
TMEM38A Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
33,260 Da
NCBI Official Full Name
Transmembrane protein 38A
NCBI Official Synonym Full Names
transmembrane protein 38A
NCBI Official Symbol
TMEM38A
NCBI Official Synonym Symbols
TRICA; TRIC-A
NCBI Protein Information
trimeric intracellular cation channel type A
UniProt Protein Name
Trimeric intracellular cation channel type A
Protein Family
UniProt Gene Name
TMEM38A
UniProt Synonym Gene Names
TRIC-A; TRICA
UniProt Entry Name
TM38A_HUMAN
Uniprot Description
TMEM38A: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Belongs to the TMEM38 family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: sarcoplasmic reticulum membrane; nuclear membrane; integral to membrane
Molecular Function: potassium channel activity
Research Articles on TMEM38A
Similar Products
Product Notes
The TMEM38A tmem38a (Catalog #AAA150362) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMEM38A Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TMEM38A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). TMEM38A antibody can be used for detection of TMEM38A by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the TMEM38A tmem38a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMEM38A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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