Rabbit anti-Human LSM6 Polyclonal Antibody | anti-LSM6 antibody

LSM6 Antibody

Cat. Num. AAA1496618

• Gene Names: LSM6; YDR378C
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: LSM6; Polyclonal Antibody; LSM6 Antibody; U6 snRNA-associated Sm-like protein LSm6; anti-LSM6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 80

• Applicable Applications for anti-LSM6 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human U6 snRNA-associated Sm-like protein LSm6 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74960 / sc-74961 / sc-74962 / sc-98326
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-LSM6 antibody

Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 5901998
• NCBI GeneID: 11157
• NCBI Accession #: NP_009011.1
• NCBI GenBank Nucleotide #: NM_007080.2
• UniProt Accession #: P62312; Q4W5J5; Q9Y4Y8
• Molecular Weight: 9,128 Da
• NCBI Official Full Name: U6 snRNA-associated Sm-like protein LSm6
• NCBI Official Synonym Full Names: LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
• NCBI Official Symbol: LSM6
• NCBI Official Synonym Symbols: YDR378C
• NCBI Protein Information: U6 snRNA-associated Sm-like protein LSm6
• UniProt Protein Name: U6 snRNA-associated Sm-like protein LSm6
• Protein Family: U6 snRNA-associated Sm-like protein
• UniProt Gene Name: LSM6
• UniProt Entry Name: LSM6_HUMAN

NCBI Description

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Uniprot Description

LSM6: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'- terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre- rRNAs and U3 snoRNA. Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.

Protein type: Spliceosome; RNA processing

Chromosomal Location of Human Ortholog: 4q31.22

Cellular Component: cytosol; nucleolus; nucleoplasm; small nuclear ribonucleoprotein complex; small nucleolar ribonucleoprotein complex; spliceosome; U4/U6 x U5 tri-snRNP complex

Molecular Function: protein binding; RNA binding

Biological Process: gene expression; maturation of SSU-rRNA; mRNA catabolic process, deadenylation-dependent decay; nuclear mRNA splicing, via spliceosome; RNA splicing; tRNA processing