Rabbit anti-Rat Ephrin-A5 Polyclonal Antibody | anti-Efna5 antibody

Rabbit anti-Rat Ephrin-A5 polyclonal Antibody, HRP conjugated

Cat. Num. AAA1489831

• Gene Names: Efna5; Lerk7
• Reactivity: Rat
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: Ephrin-A5; Polyclonal Antibody; Rabbit anti-Rat Ephrin-A5 polyclonal Antibody; HRP conjugated; AL-1; EPH-related receptor tyrosine kinase ligand 7; Efna5; Eplg7; Lerk7; anti-Efna5 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 228

• Applicable Applications for anti-Efna5 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: HRP
• Immunogen: Recombinant Rat Ephrin-A5 protein
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-Efna5 antibody

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion

NCBI and Uniprot Product Information

• NCBI GI #: 16758778
• NCBI GeneID: 116683
• NCBI Accession #: NP_446355.1
• NCBI GenBank Nucleotide #: NM_053903.1
• UniProt Accession #: P97605
• Molecular Weight: 26,358 Da
• NCBI Official Full Name: ephrin-A5
• NCBI Official Synonym Full Names: ephrin A5
• NCBI Official Symbol: Efna5
• NCBI Official Synonym Symbols: Lerk7
• NCBI Protein Information: ephrin-A5
• UniProt Protein Name: Ephrin-A5
• Protein Family: Ephrin
• UniProt Gene Name: Efna5
• UniProt Synonym Gene Names: Eplg7; Lerk7; LERK-7
• UniProt Entry Name: EFNA5_RAT

NCBI Description

Ephrin-related tryosine-kinase receptor, designated ephrin-A5 based on structure and sequence relationships; implicated in nervous system development, particularly with axon pathfinding and fasciculation [RGD, Feb 2006]

Uniprot Description

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion ().