Vps20-Associated 1 Homolog Recombinant Protein | VTA1 recombinant protein

Recombinant Human Vps20-Associated 1 Homolog

Cat. Num. AAA145377

• Gene Names: VTA1; DRG1; LIP5; SBP1; DRG-1; My012; C6orf55; HSPC228
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Vps20-Associated 1 Homolog; Recombinant Human Vps20-Associated 1 Homolog; VTA1 Human; Vps20-Associated 1 Homolog Human Recombinant; Vacuolar protein sorting-associated protein VTA1 homolog; Dopamine-responsive gene 1 protein; DRG-1; LYST-interacting protein 5; LIP5; SKD1-binding protein 1; SBP1; VTA1; C6orf55; DRG1My012; HSPC228; VTA1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: VTA1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 10% glycerol and 200mM NaCl.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAALAP LPPLPAQFKS IQHHLRTAQE HDKRDPVVAY YCRLYAMQTG MKIDSKTPEC RKFLSKLMDQ LEALKKQLGD NEAITQEIVG CAHLENYALK MFLYADNEDR AGRFHKNMIK SFYTASLLID VITVFGELTD ENVKHRKYAR WKATYIHNCL KNGETPQAGP VGIEEDNDIE ENEDAGAASL PTQPTQPSSS STYDPSNMPS GNYTGIQIPP GAHAPANTPA EVPHSTGVAS NTIQPTPQTI PAIDPALFNT ISQGDVRLTP EDFARAQKYC KYAGSALQYE DVSTAVQNLQ KALKLLTTGR E
• Sequence Length: 280

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for VTA1 recombinant protein

Description: VTA1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 331 amino acids (1-307 a.a.) and having a molecular mass of 36.5kDa.VTA1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Vps20-associated 1 homolog (VTA1) is a member of the VTA1 family. The VTA1 protein is involved in the endosomal multivesicular bodies (MVB) pathway. Furthermore, VTA1 is interacts with CHMP1B, CHMP2A, CHMP5, VPS4B, KIAA0174 (IST1) and possibly CHMP3. VTA1 is believed to be a cofactor of VPS4A/B, which catalyzes membrane-associated ESCRT-III assemblies. In addition, VTA1 is involved in the sorting and down-regulation of EGFR and also in HIV-1 budding.

Product Categories/Family for VTA1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Chromosome Open Reading Frame

NCBI and Uniprot Product Information

• NCBI GI #: 556503352
• NCBI GeneID: 51534
• NCBI Accession #: NP_001273300.1
• NCBI GenBank Nucleotide #: NM_001286371.1
• UniProt Accession #: Q9NP79; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9P0Q0; B4DW55; E1P594; E7ETQ7
• Molecular Weight: 24,553 Da
• NCBI Official Full Name: vacuolar protein sorting-associated protein VTA1 homolog isoform b
• NCBI Official Synonym Full Names: vesicle (multivesicular body) trafficking 1
• NCBI Official Symbol: VTA1
• NCBI Official Synonym Symbols: DRG1; LIP5; SBP1; DRG-1; My012; C6orf55; HSPC228
• NCBI Protein Information: vacuolar protein sorting-associated protein VTA1 homolog; LYST-interacting protein 5; SKD1-binding protein 1; Vps20-associated 1 homolog; dopamine-responsive gene 1 protein; homolog of mouse SKD1-binding protein 1
• UniProt Protein Name: Vacuolar protein sorting-associated protein VTA1 homolog
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VTA1
• UniProt Synonym Gene Names: C6orf55; DRG-1; LIP5; SBP1
• UniProt Entry Name: VTA1_HUMAN

NCBI Description

C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008]

Uniprot Description

VTA1: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding. Belongs to the VTA1 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 6q24.1

Cellular Component: endosome membrane; cytosol

Molecular Function: protein binding

Biological Process: protein transport; viral reproduction; viral infectious cycle; endosome transport