Dual Specificity Phosphatase 19 Recombinant Protein | DUSP19 recombinant protein

Recombinant Human Dual Specificity Phosphatase 19

Cat. Num. AAA144434

• Gene Names: DUSP19; SKRP1; DUSP17; LMWDSP3; TS-DSP1
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Dual Specificity Phosphatase 19; Recombinant Human Dual Specificity Phosphatase 19; DUSP19 Human; Dual Specificity Phosphatase 19 Human Recombinant; Dual specificity protein phosphatase 19; Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3; LMW-DSP3; Protein phosphatase; SKRP1; Stress-activated protein kinase pathway-regulating phosphatase 1; SAPK pathway-regulating phosphatase 1; DUSP19; DUSP17; LMWDSP3; TS-DSP1; DUSP19 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: The DUSP19 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.1M NaCl.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSQVGVIKP WLLLGSQDAA HDLDTLKKNK VTHILNVAYG VENAFLSDFT YKSISILDLP ETNILSYFPE CFEFIEEAKR KDGVVLVHCN AGVSRAAAIV IGFLMNSEQT SFTSAFSLVK NARPSICPNS GFMEQLRTYQ EGKESNKCDR IQENSS.
• Sequence Length: 166

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for DUSP19 recombinant protein

Description: DUSP19 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 176 amino acids (65-217) and having a molecular mass of 19.4kDa.DUSP19 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: DUSPs are distinguished by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSPs have been implicated as major modulators of critical signaling pathways. Dual specificity phosphatase 19 (DUSP19) belongs to the dual specificity protein phosphatase subfamily. DUSP19 is a protein phosphatase which functions as a stress-activated protein kinase pathway-regulating phosphatase. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP class of DUSPs.

Product Categories/Family for DUSP19 recombinant protein

Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 214832050
• NCBI GeneID: 142679
• NCBI Accession #: NP_001135786.1
• NCBI GenBank Nucleotide #: NM_001142314.1
• UniProt Accession #: Q8WTR2; Q547H4; Q8WYN4; B2RA79
• Molecular Weight: 18,296 Da
• NCBI Official Full Name: dual specificity protein phosphatase 19 isoform 2
• NCBI Official Synonym Full Names: dual specificity phosphatase 19
• NCBI Official Symbol: DUSP19
• NCBI Official Synonym Symbols: SKRP1; DUSP17; LMWDSP3; TS-DSP1
• NCBI Protein Information: dual specificity protein phosphatase 19; LMW-DSP3; SAPK pathway-regulating phosphatase 1; dual specificity phosphatase TS-DSP1; low molecular weight dual specificity phosphatase 3; protein phosphatase SKRP1; stress-activated protein kinase pathway-regulating phosphatase 1
• UniProt Protein Name: Dual specificity protein phosphatase 19
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP19
• UniProt Synonym Gene Names: DUSP17; LMWDSP3; SKRP1; LMW-DSP3; SAPK pathway-regulating phosphatase 1
• UniProt Entry Name: DUS19_HUMAN

NCBI Description

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Uniprot Description

DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: cytoplasm

Molecular Function: protein tyrosine/threonine phosphatase activity; JUN kinase phosphatase activity; MAP-kinase scaffold activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity

Biological Process: negative regulation of JNK activity; positive regulation of JNK activity; negative regulation of JNK cascade; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity; JNK cascade; positive regulation of JNK cascade; negative regulation of protein kinase activity; protein amino acid dephosphorylation; inactivation of MAPK activity