Rabbit DUSP19 Polyclonal Antibody | anti-DUSP19 antibody

DUSP19 Polyclonal Antibody

Cat. Num. AAA2522019

• Gene Names: DUSP19; SKRP1; DUSP17; LMWDSP3; TS-DSP1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: DUSP19; Polyclonal Antibody; DUSP19 Polyclonal Antibody; SKRP1; DUSP17; LMWDSP3; TS-DSP1; anti-DUSP19 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.3mg/mL (varies by lot)
• Sequence Length: 217

• Applicable Applications for anti-DUSP19 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Recombinant protein of human DUSP19
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DUSP19 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using DUSP19 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-DUSP19 antibody

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs.

Product Categories/Family for anti-DUSP19 antibody

Epigenetics

NCBI and Uniprot Product Information

• NCBI GI #: 29840769
• NCBI GeneID: 142679
• Molecular Weight: 18,296 Da
• NCBI Official Full Name: Dual specificity protein phosphatase 19
• NCBI Official Synonym Full Names: dual specificity phosphatase 19
• NCBI Official Symbol: DUSP19
• NCBI Official Synonym Symbols: SKRP1; DUSP17; LMWDSP3; TS-DSP1
• NCBI Protein Information: dual specificity protein phosphatase 19; LMW-DSP3; SAPK pathway-regulating phosphatase 1; dual specificity phosphatase TS-DSP1; low molecular weight dual specificity phosphatase 3; protein phosphatase SKRP1; stress-activated protein kinase pathway-regulating phosphatase 1
• UniProt Protein Name: Dual specificity protein phosphatase 19
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP19
• UniProt Synonym Gene Names: DUSP17; LMWDSP3; SKRP1; LMW-DSP3; SAPK pathway-regulating phosphatase 1
• UniProt Entry Name: DUS19_HUMAN

NCBI Description

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Uniprot Description

DUSP19: Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: cytoplasm

Molecular Function: protein tyrosine/threonine phosphatase activity; JUN kinase phosphatase activity; MAP-kinase scaffold activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity

Biological Process: negative regulation of JNK activity; negative regulation of JNK cascade; positive regulation of JNK activity; positive regulation of MAPKKK cascade; positive regulation of protein kinase activity; negative regulation of protein kinase activity; positive regulation of JNK cascade; JNK cascade; protein amino acid dephosphorylation; inactivation of MAPK activity