Cyclin-Dependent Kinase Inhibitor 3 Recombinant Protein | CDKN3 recombinant protein

Recombinant Human Cyclin-Dependent Kinase Inhibitor 3

Cat. Num. AAA144188

• Gene Names: CDKN3; KAP; CDI1; CIP2; KAP1
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Cyclin-Dependent Kinase Inhibitor 3; Recombinant Human Cyclin-Dependent Kinase Inhibitor 3; CDKN3 Human; Cyclin-Dependent Kinase Inhibitor 3 Human Recombinant; Cyclin-dependent kinase inhibitor 3; CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase; KAP; CDI1; CIP2; KAP1; FLJ25787; MGC70625; CDKN3; CDKN3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: The CDKN3 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 40% glycerol and 0.1M NaCl.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR
• Sequence Length: 172

• Preparation and Storage: CDKN3 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Related Product Information for CDKN3 recombinant protein

Description: CDKN3 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 232 amino acids (1-212 a.a.) and having a molecular mass of 25.9kDa. The CDKN3 is purified by proprietary chromatographic techniques.

Introduction: Cyclin-dependent kinase inhibitor 3 (CDKN3) is a member of the dual specificity protein phosphatase family. CDKN3 was identified as a cyclin-dependent kinase inhibitor, and was shown to interact with, and dephosphorylate CDK2 kinase, consequently prevent the activation of CDK2 kinase. In addition CDKN3 is important in cell cycle regulation. The CDKN3 gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.

Product Categories/Family for CDKN3 recombinant protein

Protein Kinases; Enzymes; Cyclin-Dependent Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 195927025
• NCBI GeneID: 1033
• NCBI Accession #: NP_001124323.1
• NCBI GenBank Nucleotide #: NM_001130851.1
• UniProt Accession #: Q16667; Q53ZU6; Q5U0M4; Q6P1N8; Q99585; Q9BPW7; Q9BY36; Q9C042; Q9C046; Q9C047; Q9C049; Q9C051
• Molecular Weight: 19,359 Da
• NCBI Official Full Name: cyclin-dependent kinase inhibitor 3 isoform 2
• NCBI Official Synonym Full Names: cyclin-dependent kinase inhibitor 3
• NCBI Official Symbol: CDKN3
• NCBI Official Synonym Symbols: KAP; CDI1; CIP2; KAP1
• NCBI Protein Information: cyclin-dependent kinase inhibitor 3; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; Cdk-associated protein phosphatase; cyclin-dependent kinase interacting protein 2; cyclin-dependent kinase interactor 1; cyclin-dependent kinase-interacting protein 2; kinase associated phosphatase; kinase-associated phosphatase
• UniProt Protein Name: Cyclin-dependent kinase inhibitor 3
• Protein Family: Cyclin-dependent kinase inhibitor
• UniProt Gene Name: CDKN3
• UniProt Synonym Gene Names: CDI1; CIP2; KAP
• UniProt Entry Name: CDKN3_HUMAN

NCBI Description

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Description

CDKN3: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity; Cell cycle regulation; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 14q22

Cellular Component: perinuclear region of cytoplasm; cytoplasm

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein serine/threonine phosphatase activity

Biological Process: negative regulation of cell proliferation; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G1/S transition of mitotic cell cycle

Disease: Hepatocellular Carcinoma