Snurportin 1 Recombinant Protein | SNUPN recombinant protein

Recombinant Human Snurportin 1

Cat. Num. AAA144054

• Gene Names: SNUPN; KPNBL; RNUT1; Snurportin1
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Snurportin 1; Recombinant Human Snurportin 1; SNUPN Human; Snurportin 1 Human Recombinant; KPNBL; RNUT1; Snurportin1; SPN1; RNA U transporter 1; SNUPN recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: SNUPN Human solution containing 20mM Tris pH-8, 2mM DTT, 0.1M NaCl, & 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MEELSQALAS SFSVSQDLNS TAAPHPRLSQ YKSKYSSLEQ SERRRRLLEL QKSKRLDYVN HARRLAEDDW TGMESEEENK KDDEEMDIDT VKKLPKHYAN QLMLSEWLID VPSDLGQEWI VVVCPVGKRA LIVASRGSTS AYTKSGYCVN RFSSLLPGGN RRNSTAKDYT ILDCIYNEVN QTYYVLDVMC WRGHPFYDCQ TDFRFYWMHS KLPEEEGLGE KTKLNPFKFV GLKNFPCTPE SLCDVLSMDF PFEVDGLLFY HKQTHYSPGS TPLVGWLRPY MVSDVLGVAV PAGPLTTKPD YAGHQLQQIM EHKKSQKEGM KEKLTHKASE NGHYELEHLS TPKLKGSSHS PDHPGCLMEN
• Sequence Length: 360

• Preparation and Storage: SNUPN Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

Related Product Information for SNUPN recombinant protein

Description: SNUPN Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 380 amino acids (1-360 a.a.) and having a molecular mass of 43.3 kDa. The SNUPN is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: SNUPN is a nuclear import adaptor protein which is part of the Snurportin family. SNUPN is Localized to the cytoplasm and nucleus and contains an N-terminal IBB domain and a trimethylguanosine (m3G)-cap binding domain. SNUPN binds specifically the terminal 2,2,7-m3G-cap at the 5'' end of U snRNPs and is involved in transport of U snRNPs into the nucleus through an association with Importin beta.

Product Categories/Family for SNUPN recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 110611149
• NCBI GeneID: 10073
• NCBI Accession #: NP_001036046.1
• NCBI GenBank Nucleotide #: NM_001042581.1
• UniProt Accession #: O95149; A6NE34; A8K0B0; D3DW76
• Molecular Weight: 41,143 Da
• NCBI Official Full Name: snurportin-1
• NCBI Official Synonym Full Names: snurportin 1
• NCBI Official Symbol: SNUPN
• NCBI Official Synonym Symbols: KPNBL; RNUT1; Snurportin1
• NCBI Protein Information: snurportin-1; RNA U transporter 1; RNA, U transporter 1
• UniProt Protein Name: Snurportin-1
• UniProt Gene Name: SNUPN
• UniProt Synonym Gene Names: RNUT1; SPN1
• UniProt Entry Name: SPN1_HUMAN

NCBI Description

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RNUT1: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family.

Protein type: Nuclear import; RNA-binding

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: nuclear pore; cytosol

Molecular Function: protein transporter activity; RNA cap binding

Biological Process: spliceosomal snRNP biogenesis; protein import into nucleus; gene expression