Rabbit anti-Human SNUPN Polyclonal Antibody | anti-SNUPN antibody

SNUPN, ID (SNUPN, RNUT1, SPN1, Snurportin-1, RNA U transporter 1) (Biotin)

Cat. Num. AAA6349476

• Gene Names: SNUPN; KPNBL; RNUT1; Snurportin1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SNUPN; Polyclonal Antibody; ID (SNUPN; RNUT1; SPN1; Snurportin-1; RNA U transporter 1) (Biotin); RNA U transporter 1; anti-SNUPN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SNUPN antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SNUPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the Central region of human SNUPN.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SNUPN Antibody (Center) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the SNUPN antibody detected the SNUPN protein (arrow).)

Related Product Information for anti-SNUPN antibody

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Product Categories/Family for anti-SNUPN antibody

Antibodies; Transport Proteins

References

Goette, M., et al. Biophys. J. 97(2):581-589(2009). Monecke, T., et al. Science 324(5930):1087-1091(2009). Ospina, J.K., et al. Mol. Biol. Cell 16(10):4660-4671(2005). Stelzl, U., et al. Cell 122(6):957-968(2005). Strasser, A., et al. EMBO J. 24(13):2235-2243(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 110611149
• NCBI GeneID: 10073
• NCBI Accession #: NP_001036046.1; NP_005692.1; NP_001036053.1
• NCBI GenBank Nucleotide #: NM_001042581.1
• UniProt Accession #: O95149; A6NE34; A8K0B0; D3DW76
• Molecular Weight: 41,143 Da
• NCBI Official Full Name: snurportin-1
• NCBI Official Synonym Full Names: snurportin 1
• NCBI Official Symbol: SNUPN
• NCBI Official Synonym Symbols: KPNBL; RNUT1; Snurportin1
• NCBI Protein Information: snurportin-1; RNA U transporter 1; RNA, U transporter 1
• UniProt Protein Name: Snurportin-1
• UniProt Gene Name: SNUPN
• UniProt Synonym Gene Names: RNUT1; SPN1
• UniProt Entry Name: SPN1_HUMAN

NCBI Description

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RNUT1: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family.

Protein type: Nuclear import; RNA-binding

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: nuclear pore; cytosol

Molecular Function: protein transporter activity; RNA cap binding

Biological Process: spliceosomal snRNP biogenesis; protein import into nucleus; gene expression