N-Acetyltransferase 6 Recombinant Protein | NAT6 recombinant protein

Recombinant Human N-Acetyltransferase 6

Cat. Num. AAA143710

• Gene Names: NAT6; FUS2; FUS-2
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: N-Acetyltransferase 6; Recombinant Human N-Acetyltransferase 6; NAT6 Human; N-Acetyltransferase 6 Human Recombinant; Protein fusion-2; FUS2; FUS-2; NAT6; N-acetyltransferase 6; Protein fus-2; NAT6 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: The NAT6 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl and 20% Glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MQELTLSPGP AKLTPTLDPT HRMELILSTS PAELTLDPAC QPKLPLDSTC QPEMTFNPGP TELTLDPEHQ PEETPAPSLA ELTLEPVHRR PELLDACADL INDQWPRSRT SRLHSLGQSS DAFPLCLMLL SPHPTLEAAP VVVGHARLSR VLNQPQSLLV ETVVVARALR GRGFGRRLME GLEVFARARG FRKLHLTTHD QVHFYTHLGY QLGEPVQGLV FTSRRLPATL LNAFPTAPSP RPPRKAPNLT AQAAPRGPKG PPLPPPPPLP ECLTISPPVP SGPPSKSLLE TQYQNVRGRP IFWMEKDI
• Sequence Length: 286

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for NAT6 recombinant protein

Description: Recombinant Human NAT6 produced in E Coli is a single, non-glycosylated polypeptide chain containing 328 amino acids (1-308 a.a.) and having a molecular mass of 35.9 kDa. NAT6 is fused to 20 amino acid His Tag at N-terminus and purified by conventional chromatography techniques.

Introduction: NAT6 is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to acrylamines. NAT6 is located mainly in the cytoplasm and its activity has been recognized by its feasibility to acetylate the N-terminus of proteins using a ping-pong-like mechanism and by its substrate specificity. Given that the NAT6 gene maps to the chromosomal region 3p21.3, which includes at least one tumor suppressor gene, the function of NAT6 plays an important role in cancer.

Product Categories/Family for NAT6 recombinant protein

Enzymes; Transferase

NCBI and Uniprot Product Information

• NCBI GI #: 318037386
• NCBI GeneID: 24142
• NCBI Accession #: NP_001186945.1
• NCBI GenBank Nucleotide #: NM_001200016.1
• UniProt Accession #: Q93015; Q93014
• Molecular Weight: 33,831 Da
• NCBI Official Full Name: N-acetyltransferase 6 isoform 2
• NCBI Official Synonym Full Names: N-acetyltransferase 6 (GCN5-related)
• NCBI Official Symbol: NAT6
• NCBI Official Synonym Symbols: FUS2; FUS-2
• NCBI Protein Information: N-acetyltransferase 6; protein fusion-2
• UniProt Protein Name: N-acetyltransferase 6
• Protein Family: N-acetyltransferase
• UniProt Gene Name: NAT6
• UniProt Synonym Gene Names: FUS2; Protein fus-2
• UniProt Entry Name: NAT6_HUMAN

NCBI Description

This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Uniprot Description

NAT6: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor. Belongs to the acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerophospholipid; Tumor suppressor; Acetyltransferase; Amino Acid Metabolism - phenylalanine; EC 2.3.1.-; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cytoplasm

Molecular Function: N-acetyltransferase activity

Biological Process: metabolic process