N-acetyltransferase 6 Recombinant Protein | NAT6 recombinant protein

N-acetyltransferase 6, 1-308aa, Human, His tag, E Coli

Cat. Num. AAA203177

• Gene Names: NAT6; FUS2; FUS-2
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: N-acetyltransferase 6; 1-308aa; Human; His tag; E Coli; Protein fusion-2; FuS2; FuS-2; NAT6; FuS 2; N acetyltransferase 6; Protein fus 2; Protein fusion 2.; NAT6 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Mes buffer (pH 5.0) containing 150mM NaCl, 30% glycerol.
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MQELTLSPGP AKLTPTLDPT HRMELILSTS PAELTLDPAC QPKLPLDSTC QPEMTFNPGP TELTLDPEHQ PEETPAPSLA ELTLEPVHRR PELLDACADL INDQWPRSRT SRLHSLGQSS DAFPLCLMLL SPHPTLEAAP VVVGHARLSR VLNQPQSLLV ETVVVARALR GRGFGRRLME GLEVFARARG FRKLHLTTHD QVHFYTHLGY QLGEPVQGLV FTSRRLPATL LNAFPTAPSP RPPRKAPNLT AQAAPRGPKG PPLPPPPPLP ECLTISPPVP SGPPSKSLLE TQYQNVRGRP IFWMEKDI
• Sequence Length: 308

• Applicable Applications for NAT6 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for NAT6 recombinant protein

N-acetyltransferase, also known as FuS2 (NAT6), is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to acrylamines. This enzyme is physically localized in the cytoplasm and its activity has been documented by its feasibility to acetylate the N-terminus of proteins using a ping-pong-like mechanism and by its substrate specificity. Since the Fus-2 gene maps to the chromosomal region 3p21.3, which contains at least one tumor suppressor gene, the N-acetyltransferase functions of Fus-2 may be relevant to its potential role in cancer. Recombinant human N-acetyltransferase 6 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.

Product Categories/Family for NAT6 recombinant protein

Enzymes & Proteases

References

Zegerman P., et al. (2000). Oncogene. 19 (1):161-3.; Gatphayak K., et al. (2004). Gene. 337:105-11;

NCBI and Uniprot Product Information

• NCBI GI #: 46048439
• NCBI GeneID: 24142
• NCBI Accession #: NP_036323
• NCBI GenBank Nucleotide #: NM_012191.3
• UniProt Accession #: Q93015; Q93014
• Molecular Weight: 35.9 kDa (328aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
• NCBI Official Full Name: N-acetyltransferase 6 isoform 1
• NCBI Official Synonym Full Names: N-acetyltransferase 6
• NCBI Official Symbol: NAT6
• NCBI Official Synonym Symbols: FUS2; FUS-2
• NCBI Protein Information: N-acetyltransferase 6
• UniProt Protein Name: N-acetyltransferase 6
• Protein Family: N-acetyltransferase
• UniProt Gene Name: NAT6
• UniProt Synonym Gene Names: FUS2; Protein fus-2

NCBI Description

This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Uniprot Description

Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.