Kell Metallo-Endopeptidase Recombinant Protein | mKEL recombinant protein
Recombinant Mouse Kell Metallo-Endopeptidase
Gene Names
Kel; Ece3; CD238
Purity
Greater than 90.0% as determined by SDS-PAGE
Synonyms
Kell Metallo-Endopeptidase; Recombinant Mouse Kell Metallo-Endopeptidase; mKEL; KEL Mouse; Kell Metallo-Endopeptidase Mouse Recombinant; kell blood group antigen; kell blood group glycoprotein; Kell blood group; Kell blood group glycoprotein homolog; KEL; Kell; CD238 antigen; CD238; ECE3; Kell blood group-metalloendopeptidase; mKEL recombinant protein
Host
Sf9, Baculovirus cells
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE
Form/Format
Sterile filtered colorless solution.
The KEL solution (0.25mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH7.4).
The KEL solution (0.25mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH7.4).
Sequence
ADPIFRNCGP CPCETPVCME LLDHYLASGN RSVAPCTDFF SFACEKANGT SDSFQALTEE NKSRLWRLLE APGSWHLGSG EEKAFQFYNS CMDTDAIEAS GSGPLIQIIE ELGGWNITGN WTSLDFNQNL RLLMSQYGHF PFFRAYLRpHPAPPHTPIIQ IDQPEFDILL QQEQEQKVYA QILREYVTYL NRLGTLLGSN PQEAQQHASW SIVFTSRLFQ FLRPQQQQQA QDKLFHVVTI DELQEMAPAI DWLSCLQAIF TPMSLNSSQT LVVHDLDYLR NMSQLVEEGL LNHRESIQSY MILGLVDTLS PALDTKFQEA RRELIQELRK LKERPPLPAY PRWMKCVEQT GAFFEPTLAA LFVREAFGPS IQSAAMELFA EIKDAVIIRL KKLSWISEET QKEALNKLAQ LQVEMGAPKR AVKPDIATQE YNDIQLGPSF LQSFLSCVRS LRARNVQSFL QPFPYHRWQK SPWEVNAYYS ISDHMVVFPA GLLQPPFFHP GYPRAVNFGA AGSIMAHELL HIFYQLLLPG GCPACDTHVL QEALLCLERH YAAFPLPSIS SFNGSHTLLE NAADIGGVAI AFQAYSKRIV EHTGELTLPN LDLSPYQLFF RSYAQVMCRG LSSQDPQDpHSPPSLRVHGP LSNTPDFAKH FHCPRGTLLN PSARCKLWHH HHHH
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Store, frozen at -20 degree C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Related Product Information for mKEL recombinant protein
Kell blood group glycoprotein homolog or KEL, is an enzyme, part of the zinc endopeptidase of the neprilysin (NEP) group of proteins. KEL has a crucial part in the production of the potent bioactive ET-3, which also includes enzymes that are endothelin convertingenzymes (PEX, XCE, DINE &various NEP-like proteins). KEL uses a single disulfide bond to XK, a gated membranal transporter. The Kell antigen system that includes two proteins, is very crucial among blood group systems.
KEL Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 674 amino acids (49-713 aa) and having a molecular mass of 76.3kDa.
KEL is fused to a 9 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
KEL Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 674 amino acids (49-713 aa) and having a molecular mass of 76.3kDa.
KEL is fused to a 9 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
Product Categories/Family for mKEL recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
80,866 Da
NCBI Official Full Name
kell blood group glycoprotein homolog
NCBI Official Synonym Full Names
Kell blood group
NCBI Official Symbol
Kel
NCBI Official Synonym Symbols
Ece3; CD238
NCBI Protein Information
kell blood group glycoprotein homolog; Kell protein; Kel blood group protein; Kell blood group, metallo-endopeptidase
UniProt Protein Name
Kell blood group glycoprotein homolog
UniProt Gene Name
Kel
UniProt Entry Name
KELL_MOUSE
Uniprot Description
Function: Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3
By similarity. Ref.1
Cofactor: Binds 1 zinc ion per subunit
By similarity.
Subunit structure: Heterodimer with XK; disulfide-linked. Ref.1
Subcellular location: Cell membrane; Single-pass type II membrane protein
By similarity. Note: Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton
By similarity.
Tissue specificity: Highly expressed in spleen. Weaker expression in testis and heart. Ref.1
Post-translational modification: N-glycosylated. Ref.1
Sequence similarities: Belongs to the peptidase M13 family.
Research Articles on mKEL
Similar Products
Product Notes
The mKEL kel (Catalog #AAA141587) is a Recombinant Protein produced from Sf9, Baculovirus cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ADPIFRNCGP CPCETPVCME LLDHYLASGN RSVAPCTDFF SFACEKANGT SDSFQALTEE NKSRLWRLLE APGSWHLGSG EEKAFQFYNS CMDTDAIEAS GSGPLIQIIE ELGGWNITGN WTSLDFNQNL RLLMSQYGHF PFFRAYLRpH PAPPHTPIIQ IDQPEFDILL QQEQEQKVYA QILREYVTYL NRLGTLLGSN PQEAQQHASW SIVFTSRLFQ FLRPQQQQQA QDKLFHVVTI DELQEMAPAI DWLSCLQAIF TPMSLNSSQT LVVHDLDYLR NMSQLVEEGL LNHRESIQSY MILGLVDTLS PALDTKFQEA RRELIQELRK LKERPPLPAY PRWMKCVEQT GAFFEPTLAA LFVREAFGPS IQSAAMELFA EIKDAVIIRL KKLSWISEET QKEALNKLAQ LQVEMGAPKR AVKPDIATQE YNDIQLGPSF LQSFLSCVRS LRARNVQSFL QPFPYHRWQK SPWEVNAYYS ISDHMVVFPA GLLQPPFFHP GYPRAVNFGA AGSIMAHELL HIFYQLLLPG GCPACDTHVL QEALLCLERH YAAFPLPSIS SFNGSHTLLE NAADIGGVAI AFQAYSKRIV EHTGELTLPN LDLSPYQLFF RSYAQVMCRG LSSQDPQDpH SPPSLRVHGP LSNTPDFAKH FHCPRGTLLN PSARCKLWHH HHHH. It is sometimes possible for the material contained within the vial of "Kell Metallo-Endopeptidase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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