A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14) Recombinant Protein | ADAMTS14 recombinant protein

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14) , partial

Cat. Num. AAA1414600

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14); Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAMTS14); partial; ADAMTS14 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,226

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ADAMTS14 recombinant protein

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined.

NCBI and Uniprot Product Information

• NCBI GI #: 21265052
• NCBI GeneID: 140766
• NCBI Accession #: NP_542453.2
• NCBI GenBank Nucleotide #: NM_080722.4
• UniProt Accession #: Q8WXS8; Q5T4G0; Q5T4G1; Q8TE55; Q8TEY8
• Molecular Weight: 134,205 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform 2 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif 14
• NCBI Official Symbol: ADAMTS14
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 14
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 14
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: ADAMTS14
• UniProt Synonym Gene Names: ADAM-TS 14; ADAM-TS14; ADAMTS-14

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]

Uniprot Description

Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.