Western Blot (WB)
(Mouse Epha2 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Epha2 antibody detected the Epha2 protein (arrow).)
Rabbit anti-Mouse Epha2 Polyclonal Antibody | anti-Epha2 antibody
Mouse Epha2 Antibody (Center)
Western Blot (WB)
(Mouse Epha2 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Epha2 antibody detected the Epha2 protein (arrow).)
Western Blot (WB)
(Mouse Epha2 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Epha2 antibody detected the Epha2 protein (arrow).)
Kim, J., et al. Mol. Cell. Biol. 30(7):1582-1592(2010)
Zirzow, S., et al. Dev. Biol. 336(2):145-155(2009)
Jun, G., et al. PLoS Genet. 5 (7), E1000584 (2009) :
North, H.A., et al. Development 136(14):2467-2476(2009)
NCBI and Uniprot Product Information
Uniprot Description
EphA2: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 AND -A5. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Overexpressed in many cancers including aggressive ovarian, cervical and breast carcinomas, and lung cancer. Expression correlates with degree of angiogenesis, metastasis and xenograft tumor growth. Soluble receptor inhibits tumor growth and angiogenesis in mice.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.10.1; TK group; Eph family
Cellular Component: focal adhesion; cell surface; cell projection; membrane; integral to plasma membrane; plasma membrane; integral to membrane; intracellular; cell junction
Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; ephrin receptor activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity
Biological Process: neural tube development; peptidyl-tyrosine phosphorylation; apoptosis; notochord formation; osteoclast differentiation; regulation of blood vessel endothelial cell migration; bone remodeling; protein amino acid phosphorylation; neuron differentiation; notochord morphogenesis; regulation of cell adhesion mediated by integrin; ephrin receptor signaling pathway; protein kinase B signaling cascade; angiogenesis; cell adhesion; vasculogenesis; cell differentiation; skeletal development; axial mesoderm formation; blood vessel development; cell migration; negative regulation of protein kinase B signaling cascade; mammary gland epithelial cell proliferation; regulation of angiogenesis; osteoblast differentiation; keratinocyte differentiation; DNA damage response, signal transduction resulting in induction of apoptosis; notochord cell development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on Epha2
Similar Products
Product Notes
The Epha2 epha2 (Catalog #AAA9210506) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 296-323. The Mouse Epha2 Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Epha2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Epha2 epha2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Epha2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
