Rabbit ADAMTS14 Polyclonal Antibody | anti-ADAMTS14 antibody

Anti-ADAMTS14 Antibody

Cat. Num. AAA417407

• Reactivity: Human. Predicted: Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: ADAMTS14; Polyclonal Antibody; Anti-ADAMTS14 Antibody; anti-ADAMTS14 antibody

• Host: Rabbit
• Reactivity: Human. Predicted: Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 1226

• Applicable Applications for anti-ADAMTS14 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA titer: 1:20,000-1:80,000; Western blot analysis: 1:500-1:1,000; Optimal dilutions/concentrations should be determined by the end user.
• Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.
• Immunogen: Rabbit polyclonal ADAMTS14(1) antibody was raised against a peptide from the intermediate residues of human ADAMTS14 protein.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-ADAMTS14 antibody

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]

References

(1) Lee,C.W., Hwang,I., Park,C.S., et al. Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina. J. Thromb. Thrombolysis 33 (4), 362-370 (2012)

NCBI and Uniprot Product Information

• NCBI GI #: 110611167
• NCBI GeneID: 140766
• NCBI Accession #: NP_631894.2
• NCBI GenBank Nucleotide #: NM_139155.2
• Molecular Weight: 134,205 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform 1 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif, 14
• NCBI Official Symbol: ADAMTS14
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 14; ADAM-TS 14; ADAM-TS14; ADAMTS-14; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14; metalloprotease-disintegrin protease
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 14
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: ADAMTS14
• UniProt Entry Name: ATS14_HUMAN

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined. [provided by RefSeq, Jul 2008]

Uniprot Description

ADAMTS14: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Motility/polarity/chemotaxis; Protease; Secreted, signal peptide; Secreted; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity

Biological Process: collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; proteolysis