Lysosomal acid lipase/cholesteryl ester hydrolase (Lipa) Recombinant Protein | Lipa recombinant protein
Recombinant Rat Lysosomal acid lipase/cholesteryl ester hydrolase (Lipa)
Gene Names
Lipa; LAL; Lip1; Chole; Chole2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Lysosomal acid lipase/cholesteryl ester hydrolase (Lipa); Recombinant Rat Lysosomal acid lipase/cholesteryl ester hydrolase (Lipa); Lipa recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
20-397, full length protein
Sequence
PTGTISAVDPEANMNVTEIIMHWGYPEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQWRHGFLADSSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQLYNVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLPDLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVDVYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWRLYNEVVSLMKKYQ
Sequence Length
378
Species
Rat
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Lipa recombinant protein
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
45,186 Da
NCBI Official Full Name
Lysosomal acid lipase/cholesteryl ester hydrolase
NCBI Official Synonym Full Names
lipase A, lysosomal acid type
NCBI Official Symbol
Lipa
NCBI Official Synonym Symbols
LAL; Lip1; Chole; Chole2
NCBI Protein Information
lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Protein Name
Lysosomal acid lipase/cholesteryl ester hydrolase
Protein Family
UniProt Gene Name
Lipa
UniProt Synonym Gene Names
Lal; Lip1; Acid cholesteryl ester hydrolase; LAL
NCBI Description
hydrolase that is involved in intracellular degradation of cholesteryl esters and triglycerides; mutation in gene causes Wolman's disease [RGD, Feb 2006]
Uniprot Description
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation ().
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Product Notes
The Lipa lipa (Catalog #AAA1409169) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 20-397, full length protein. The amino acid sequence is listed below: PTGTISAVDP EANMNVTEII MHWGYPEHSV QTGDGYILGV HRIPHGRKNQ FDKGPKPVVY LQWRHGFLAD SSNWVTNIDN NSLGFILADA GFDVWMGNSR GNTWSRKHKT LSVSQDEYWA FSFDEMAKYD LPASINYILN KTGQEQLYNV GHSQGCTIGF IAFSQMPELA KKVKMFFALA PVLSLNFASG PMVKLGRLPD LLLEDLFGQK QFLPQSAMVK WLSTHICTHV IMKELCANIF FLICGFNEKN LNMSRVDVYT THCPAGTSVQ NMVHWTQVVK YHKLQAFDWG SSDKNYFHYN QSYPPLYSIK DMQLPTALWS GGKDWLADTS DINILLTEIP TLVYHKNIPE WDHLDFIWGL DAPWRLYNEV VSLMKKYQ. It is sometimes possible for the material contained within the vial of "Lysosomal acid lipase/cholesteryl ester hydrolase (Lipa), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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